54755-95-2Relevant articles and documents
Potassium Phosphate-Catalyzed Chemoselective Reduction of α-Keto Amides: Route to Synthesize Passerini Adducts and 3-Phenyloxindoles
Muthukumar, Alagesan,Mamillapalli, N. Chary,Sekar, Govindasamy
, p. 643 - 652 (2016/02/27)
A chemoselective reduction of α-keto amides to biologically important α-hydroxy amides (mandelamides) by polymethylhydrosiloxane (PMHS) using 5 mol% potassium phosphate (K3PO4) as catalyst has been developed. This transition metal-free protocol discloses excellent chemoselectivity for the ketone reduction of α-keto amides in the presence of other reducible functionalities like ketone, nitro, halides, nitrile and amide. Also, the chemoselectively reduced α-hydroxy amide has been derivatized to isocyanide-free Passerini adducts. The N-alkyl-α-hydroxy amides have been successfully converted to 3-phenyloxindole derivatives by treatment with methanesulfonyl cholride and triethylamine.
The Chemistry of 5-Oxodihydroisoxales. XI; The Photolysis of 3-Hydroxy-4-phenylisoxazol-5(2H)-ones (Phenyldisic Acids)
Prager, Rolf H.,Smith, Jason A.
, p. 217 - 226 (2007/10/02)
3-Hydroxy-2-methyl-4-phenylisoxazol-5(2H)-one, 3-hydroxy-2,4-diphenylisoxazol-5(2H)-one and phenyldisic acid have been photolysed at 254 nm in hydroxylic solvents.By comparision of the respective products with those obtained from 3-methoxy-4-phenylisoxazo
