16446-29-0

Upstream product

• 2584-64-7 N-(thiobenzoyl)glycine 
• 7471-86-5 methyl benzimidate 
• 87386-07-0 N-(thiobenzoyl)glycine ethyl ester 
• 5873-86-9 methyl thiobenzoate 

Downstream Products

• 35317-71-6 diphenylacetic acid 4-(2-acetoxy-1-methyl-vinyl)-2-phenyl-thiazol-5-yl ester 
• 16446-03-0 4-[2-(5'-chloro-8'-methoxy-3',4'-dihydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalen]-3'-yl)-ethylidene]-2-phenyl-4H-thiazol-5-one 
• 35317-65-8 4-((Z)-2-acetoxy-1-methyl-ethylidene)-2-phenyl-4H-thiazol-5-one 
• 35317-64-7 4-(2-acetoxy-1-acetoxymethyl-ethylidene)-2-phenyl-4H-thiazol-5-one 
• 70489-49-5 4-[2-(5,7-dimethoxy-4-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-ethylidene]-2-phenyl-4H-thiazol-5-one 
• 35317-72-7 5-acetoxy-4-(2-acetoxy-1-methyl-vinyl)-2-phenyl-thiazole 
• 16446-30-3 4-benzylidene-2-phenyl-4H-thiazol-5-one 
• 69673-63-8 4-(7-hydroxy-2,2,10b-trimethyl-6-oxo-(4ar,10bc)-4a,5,6,10b-tetrahydro-4H-naphtho[1,2-d][1,3]dioxin-4c-ylmethylene)-2-phenyl-4H-thiazol-5-one 
• 24053-33-6 5-acetylsulfanyl-2-phenyl-thiazole 
• 86557-76-8 2-phenyl-4-(methyl-hydrazono)5(4H)-thiazolone 
• 70098-59-8 4-[2-(5-Hydroxy-4-oxo-thiochroman-2-yl)-eth-(Z)-ylidene]-2-phenyl-4H-thiazol-5-one 
• 70098-64-5 2-Phenyl-4<2-(8-dimethylamino-5-hydroxy-thiochroman-4-on-2-yl)-ethyliden>-2-thiazolin-5-on 
• 73725-34-5 2-phenyl-4-dimethylaminomethylene-5-thiazolone 
• 454253-33-9 trifluoromethanesulfonic acid 2-phenyl-thiazol-5-yl ester 

Relevant academic research and scientific papers

Improved erlenmeyer synthesis with 5-thiazolone and catalytic Mn(II) acetate. Crystal structure confirmation of the reaction stereochemistry

2-Phenylthiazolin-5-one (5, a thioazlactone) condenses with various aldehydes in the presence of the mild base Mn(II) acetate as catalyst in CH 2Cl2 solution. This leads to the corresponding Erlenmeyer reaction products (6) in excell

Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles

(Matrix presented) This paper describes Sonogashira cross-coupling of functionalized 2-, 4-, and 5-trifloyl oxazoles and thiazoles with terminal alkynes. This methodology has been extended to 2,4-ditrifloylthiazoles, which results in regioselective cross-coupling at the C2-position of the thiazole. The resulting 2-alkynyl-4-trifloylthiazoles are effective electrophiles in a second palladium(0)-mediated cross-coupling reaction.

REACTION OF 5(4H)-THIAZOLONES WITH DIAZOMETHANE

The reaction of diazomethane with several (Z)-2-substituted-4-benzylidene-5(4H)thiazolones (1) (2-substitution: SCH2Ph, OCH2Ph, SCH3, CH3, Ph), under two different conditions, has been studied.In benzene at 45 deg C (Z) and (E)-2-substituted-1-phenyl-7-ox

A total synthesis and structural aspects of racemic 8-oxygenated tetracyclines

A stereoselective total synthesis of the first 8-oxygenated tetracycline derivatives 43 and 4 is described. Key steps for the construction of the tetracycline skeleton are the condensation of the tetralone aldehyde 24 with the thiazolone 32 followed by co