16492-63-0

Basic information

• Product Name: 1H-Pyrazole-5-methanol, 1,3-diphenyl-
• Synonyms: 1,3-diphenyl-5-hydroxymethylpyrazole;5-Hydroxymethyl-1,3-diphenyl-pyrazol;(1,3-diphenyl-1H-pyrazol-5-yl)methanol;(2,5-diphenyl-2H-pyrazol-3-yl)-methanol;1H-Pyrazole-5-methanol,1,3-diphenyl;5-hydroxymethyl-n,3-diphenyl pyrazole
• CAS NO: 16492-63-0
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.29500
• Mol File: 16492-63-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 443.6±30.0 °C(Predicted)
• Density: 1.15±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-5-methanol, 1,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-methanol, 1,3-diphenyl-(16492-63-0)
• EPA Substance Registry System: 1H-Pyrazole-5-methanol, 1,3-diphenyl-(16492-63-0)

Safety Data

• Hazardous Substances Data: 16492-63-0(Hazardous Substances Data)

Usage

Class

Pyrazole derivatives

Structure

Contains a pyrazole ring with a hydroxyl group and two phenyl groups

Usage

Building block in the synthesis of various pharmaceuticals and biologically active compounds

Applications

Potential in the field of medicinal chemistry and drug discovery due to its structural properties and reactivity

Specific uses and properties

Vary depending on the context and specific application

Upstream product

• 107-19-7 propargyl alcohol 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 100-52-7 benzaldehyde 
• 588-64-7 benzaldehyde phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 536-74-3 phenylacetylene 
• 4918-36-9 4-(ethoxycarbonyl)-N-phenylsydnone 
• 508191-77-3 3-phenylsydnone 

Downstream Products

• 1429486-83-8 5-onofluoromethyl-1,3-diphenyl-1H-pyrazole 
• 87838-35-5 1,3‐diphenyl‐1H‐pyrazole‐5‐carbaldehyde 
• 24652-31-1 1,3-diphenyl-1H-pyrazole-5-carbonitrile 

Relevant articles and documents

Sequential [3+2] annulation reaction of prop-2-ynylsulfonium salts and hydrazonyl chlorides: Synthesis of pyrazoles containing functional motifs

A novel sequential [3+2] annulation reaction has been developed using prop-2-ynylsulfonium salts and hydrazonyl chlorides, affording a series of pyrazoles with functional motifs that can be post modified in the preparation of various drugs or drug candidates. Further transformation and gram-scale operations could also be achieved efficiently. This journal is

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.