16492-63-0Relevant academic research and scientific papers
Sequential [3+2] annulation reaction of prop-2-ynylsulfonium salts and hydrazonyl chlorides: Synthesis of pyrazoles containing functional motifs
Jia, Tingting,Liu, Shourong,Shao, Jiaan,Shi, Tao,Wu, Zhaoxiao,Zeng, Linghui,Zhang, Chong,Zhang, Jiankang,Zhu, Huajian,Zhuang, Rangxiao
, p. 8460 - 8463 (2021/09/08)
A novel sequential [3+2] annulation reaction has been developed using prop-2-ynylsulfonium salts and hydrazonyl chlorides, affording a series of pyrazoles with functional motifs that can be post modified in the preparation of various drugs or drug candidates. Further transformation and gram-scale operations could also be achieved efficiently. This journal is
La(OTf)3-catalysed one-pot synthesis of pyrazole tethered imidazo[1,2-: A] azine derivatives and evaluation of their light emitting properties
Sharma, Shubham,Paul, Avijit Kumar,Singh, Virender
supporting information, p. 684 - 694 (2020/01/31)
A facile and efficient protocol has been unfolded towards the diversity-oriented synthesis of highly fluorescent pyrazole C-3(5) tethered imidazo[1,2-a]azines via an La(OTf)3 catalysed one-pot multicomponent assembly of pyrazole carbaldehydes, 2-aminoazines and isonitriles. This present protocol offers several advantages such as multiple bond formation in a single step, low catalyst loading, short reaction time, appreciable atom economy, good functional group tolerance, scalability and easy to perform reaction conditions. The optical properties of pyrazolyl imidazo[1,2-a]azines were also studied, and they exhibited an excellent fluorescence quantum yield (ΦF up to 83%).
Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions
Foster, Robert S.,Adams, Harry,Jakobi, Harald,Harrity, Joseph P. A.
, p. 4049 - 4064 (2013/06/05)
We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.
4,5-Dihydroisoxazoles. Part 5. Addition Reactions of Diazoalkanes. Nitrile Imines and Nitrile Oxides to 3-Aryl-4-methylene-5-morpholino-4,5-dihydroisoxazoles
Ballabio, Marzia,Croce, Piero Dalla,Massari, Valeria,Pocar, Donato,Riva, Alberto,Trimarco, Pasqualina
, p. 1317 - 1340 (2007/10/02)
Some 5-morpholino-3-aryl-4-methylene-4,5-dihydroisoxazoles were reacted with nitrile oxides, diazoalkanes and nitrile imines.The corresponding cycloaddition products, namely spiro and spirobi derivatives, were obtained
