16510-81-9

Basic information

• Product Name: 3-methoxy-3-phenyl-propan-1-ol
• CAS NO: 16510-81-9
• Molecular Weight: 166.22
• Mol File: 16510-81-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-methoxy-3-phenyl-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-3-phenyl-propan-1-ol(16510-81-9)
• EPA Substance Registry System: 3-methoxy-3-phenyl-propan-1-ol(16510-81-9)

Safety Data

• Hazardous Substances Data: 16510-81-9(Hazardous Substances Data)

Upstream product

• 75-21-8 oxirane 
• 35364-99-9 α-chlorobenzyl methyl ether 
• 67-56-1 methanol 
• 4850-49-1 1-phenyl-1,3-propanediol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 538-86-3 benzyl methyl ether 
• 772-00-9 4-phenyl-1,3-dioxane 
• 873-49-4 cyclopropylbenzene 

Downstream Products

• 873-49-4 cyclopropylbenzene 
• 256229-09-1 3-methoxy-3-phenylpropanal 

Relevant articles and documents

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Metalation of arylmethyl alkyl ethers

Arylmethyl alkyl ethers 1a-11 were metallated with n-BuLi or sec-BuLi in THF at different temperatures, affording α-alkoxy-substituted arylmethyllithium derivatives. At low temperature, the organometallics derived from methyl and isopropyl ethers are suff

Investigation of the stereochemistry of Fe-Cα bond cleavage when phenylcyclopropane is generated by γ-ionization of stereospecifically deuterated C5H5(CO)2 FeCHDCHDCH(OCH3)C6H5 complexes.

C5H5(CO)2FeCH2CH 2CH(OCH3)C6H5, 4, and stereospecifically deuterium labeled threo-d2-C5H5-(CO) 2FeCHDCHDCH(OCH3)C6H5, 7a,b and erythro-d2-C5H5(CO) 2FeCHDCHDCH(OCH3)C6H5, 8a,b were synthesized. Treatment of compound 4 with trimethylsilyl triflate results in ionization of the γ-methoxy group and formation of phenylcyclopropane in good yields. Ionization of 7a,b gives a 1:1 mixture of cis-2,cis-3-dideuterio- and trans-2,trans-3-dideuterio-r-1-phenylcyclopropane, while ionization of 8a,b gives cis-2,trans-3-dideuterio-r-1-phenylcyclopropane. These results established that the cyclopropane ring is formed by backside attack of electrophilic Cγ on Cα with net inversion of stereochemistry at Cα. These reactions serve as models for the reactions of carbene complexes C5H5(CO)2Fe=CHR+ with alkenes to give cyclopropanes and suggest that in the transfer reactions Fe-Cα is cleaved with inversion.