16619-38-8Relevant academic research and scientific papers
Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors
Kasturi, Sivaprasad,Surarapu, Sujatha,Bathoju, Chandra Chary,Uppalanchi, Srinivas,Dwivedi, Shubham,Perumal, Yogeeswari,Sigalapalli, Dilep Kumar,Babu, Bathini Nagendra,Ethiraj, Krishna S.,Anireddy, Jaya Shree
, p. 1618 - 1630 (2017/08/22)
An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their α-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards. Molecular modeling studies were per
Tandem synthesis of pyrrolo[2,3-b]quinolones via cadogen-type reaction
Lin, Zhichen,Hu, Zhongyan,Zhang, Xin,Dong, Jinhuan,Liu, Jian-Biao,Chen, De-Zhan,Xu, Xianxiu
supporting information, p. 5284 - 5287 (2017/11/06)
A tandem [3 + 2] cycloaddition/reductive cyclization of nitrochalcones with activated methylene isocyanides for the efficient synthesis of pyrrolo[2,3-b]- quinolones is reported. In this reaction, the in situ generated dihydropyrroline acts as the interna
Efficient construction of 3-arylquinolin-4(1H)-ones via in situ Meinwald rearrangement/intramolecular reductive cyclization of 2′-nitrochalcone epoxides
Wang, Sheng,Zhao, Chao,Liu, Ting,Yu, Lifang,Yang, Fan,Tang, Jie
, p. 7025 - 7031 (2016/10/14)
An efficient method for construction of 3-arylquinolin-4(1H)-ones via in situ Meinwald rearrangement/intramolecular reductive cyclization of 2′-nitrochalcone epoxides has been developed. The practical approach is of excellent functional groups compatibili
Efficient Protocol for the Synthesis of Novel Spiro[acenaphthylene-1,2′-pyrrolidin]-2-one Compounds
Lin, Yan,Fu, Zhijie,Shen, Tianhua,Che, Fengfeng,Song, Qingbao
supporting information, p. 2188 - 2194 (2015/09/22)
An efficient catalyst-free synthesis of 3′-benzoyl-4′,5′-diphenyl-2H-spiro[acenaphthylene-1,2′-pyrrolidin]-2-one derivatives via one-pot 1,3-dipolar cycloaddition of acenaphthenequinone, arylmethyl amines, and chalcones with high regioselectivity is described. The structure of the cycloadducts were characterized by infrared, high-resolution mass spectrometry (electrospray ionization), 1H NMR, and 13C NMR spectra, and the structure of 4a was confirmed using x-ray single-crystal structure analysis.
Synthesis and screening antimicrobial activities of novel 1,3-diaryl-3-(phenylthio)propan-1-one derivatives
Karaman, Isa,Gezegen, Hayreddin,Ceylan, Mustafa,Dilma, Merve
experimental part, p. 580 - 586 (2012/06/01)
In this study, a series of novel β-mercapto carbonyl derivatives (3a-j) was prepared by addition of thiophenol (2) to chalcones (1a-j) in the presence of catalytic amount of iodine (10 mol%) in CH2Cl 2. Antibacterial and antifungal in vitro properties of the synthesized compounds were tested against some human pathogenic microorganisms by employing the disk diffusion technique. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
An efficient tandem aldol condensation-thia-Michael addition process
Abaee, M. Saeed,Cheraghi, Somayeh,Navidipoor, Somayeh,Mojtahedi, Mohammad M.,Forghani, Soodabeh
experimental part, p. 4405 - 4408 (2012/09/25)
An efficient synthesis of β-aryl-β-mercapto ketones is achieved via a tandem aldol condensation-thia-Michael addition process using an aqueous medium and diethylamine. Addition of different thiols to α,β- unsaturated ketones, formed in situ from the condensation of acetophenone derivatives with aldehydes, led to a rapid and high yielding synthesis of the products under very mild conditions using no expensive additive or catalyst. Products which precipitated spontaneously in the reaction mixtures were separated by simple filtration and purified by recrystallization.
Synthesis of chalcones catalysed by SOCl2/EtOH
Hu, Zhiguo,Liu, Jun,Dong, Zhibing,Guo, Lili,Wang, Dong,Zeng, Pingli
, p. 158 - 159 (2007/10/03)
A novel and efficient synthesis chalcones by using SOCl2/EtOH as catalyst was presented. In the presence of thionyl chloride, the aldol condensation of acetophenone and benzaldehyde was catalysed in the anhydrous ethanol in high yields (60-95%) under mild condition.
Synthesis of Isocoumarin, 1-Isoquinolone and 4(1H)-Quinolone Derivatives via Seleno-intermediates
Izumi, Taeko,Morishita, Nobuya
, p. 145 - 152 (2007/10/02)
The reaction of 2-styrylbenzoic acid 2 with N-phenylselenosuccinimide (N-PPS) affords 3-phenyl-iso-coumarin derivatives 3 and 3,4-dihydro-3-phenyl-4-(phenylseleno)isocoumarins 4 via selenolactonization.The reaction of 2-styrylbenzamides 5 and 1-(2-aminoph
