20358-05-8

Usage

Uses

Used in Organic Synthesis:
2-Amino-7-bromobenzothiazole is utilized as a building block in organic synthesis for the creation of various heterocyclic compounds. Its unique structure allows for the formation of diverse chemical entities, contributing to the development of new organic materials and compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-Amino-7-bromobenzothiazole serves as a key intermediate for the synthesis of pharmaceuticals. Its presence in the molecular structure can influence the pharmacological properties of the final product, making it an essential component in drug discovery and development.
Used in Dye and Pigment Production:
2-Amino-7-bromobenzothiazole is also recognized as a potential intermediate in the production of dyes and pigments. Its chemical properties make it suitable for use in the development of colorants for various applications, including textiles, plastics, and printing inks.
Used in Chemical Industry and Research Laboratories:
The chemical and physical properties of 2-Amino-7-bromobenzothiazole make it a valuable reagent in the chemical industry and research laboratories. Its versatility and reactivity contribute to a wide range of chemical processes and experiments, further expanding its applications in scientific research and industrial production.

Upstream product

• 21325-43-9 1-bromo-3-nitro-2-thiocyanato-benzene 
• 614-76-6 N-acetyl-2-bromoaniline 
• 59255-95-7 2-bromo-6-nitroaniline 
• 21327-14-0 1-(3-bromophenyl)thiourea 
• 89069-93-2 N-((3-bromophenyl)carbamothioyl)benzamide 
• 1147550-11-5 ammonium thiocyanate 
• 591-19-5 m-Bromoaniline 
• 767-70-4 7-bromo-1,3-benzothiazole 
• 3425-46-5 potassium selenocyanate 
• 56967-17-0 m-bromoaniline hydrochloride 
• 1112982-68-9 N-(7-bromobenzo[d]thiazol-2-yl)acetamide 

Downstream Products

• 16628-26-5 N-(6-bromo-1,3-benzothiazol-2-yl)acetamide 
• 1112982-68-9 N-(7-bromobenzo[d]thiazol-2-yl)acetamide 
• 1309261-87-7 C₂₁H₁₃BrN₄OS 
• 1309261-67-3 3-(7-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4(3H)-one 
• 36247-07-1 7-bromo-2-phenylbenzo[d]thiazole 

Relevant academic research and scientific papers

Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles

A facile and sustainable approach for the amination of benzothiazoles with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles

Visible-light photoredox catalytic approach for the direct synthesis of 2-aminobenzothiazoles from anilines

A novel, highly efficient and convenient approach for the visible-light-promoted direct synthesis of 2-aminobenzothiazoles from anilines and ammonium thiocyanate is presented. The reaction involves addition/cyclization cascade of SCN radical and anilines under photoredox catalysis with Ru(bpy)3Cl2. The salient features of the protocol include the utilization of atmospheric oxygen and visible light as clean, inexpensive and sustainable resources at room temperature.

COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND A ELECTRONIC DEVICE THEREOF

The present invention relates to a novel compound, to an electro-organic device using same, and to an electronic device thereof. According to the present invention, the light-emitting efficiency, the color purity, and the life of a device can be increased

JAK INHIBITORS

Disclosed is a series of JAK inhibitors, which specifically relates to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

QSAR modeling of synthesized 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potent antibacterial agents

Present communication elicits the designing and synthesis of 3-(1,3-benzothiazol-2-yl) 2-phenyl quinazolin-4(3H)-ones as potential antibacterial agents. A number of substituted 2-amino benzothiazoles, 2-amino-5-[(E)-phenyl diazenyl] benzoic acid, and 2-phenyl-4H benzo[d] [1,3] oxazin-4-one were synthesized as the precursor substrates. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of IR, 1H NMR, Mass, and elemental analysis data. These compounds were screened in vitro for their antibacterial activity against a representative panel of Gram positive and Gram negative bacteria and models were generated through quantitative structure-activity relationship (QSAR).The activity contributions due to structural and substituent effects were determined using sequential regression procedure. The antimicrobial assay data show that the synthesized compounds are found to manifest profound antimicrobial activity. Springer Science+Business Media, LLC 2011.

Solid phase synthesis of 2-aminobenzothiazoles

A traceless solid supported protocol for the synthesis of 2-aminobenzothiazoles is described, employing resin-bound acyl-isothiocyanate and a series of anilines. Cyclization of the resulting N-acyl, N′-phenyl-thioureas generates the 2-aminobenzothiazole scaffold, which can be further elaborated prior to hydrazine-mediated cleavage of the final products from the carboxy-polystyrene resin. A small, focused library of 2-aminobenzothiazoles was prepared.

PI3 KINASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.