6971-17-1

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 29976-84-9 1-(2-hydroxy-5-methylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione 
• 29976-81-6 2-anisoyloxy-5-methylacetophenone 
• 34087-19-9 2-acetyl-4-methylphenyl acetate 
• 16635-13-5 2'-hydroxy-4-methoxy-5'-methylchalcone 
• 73484-69-2 6-methyl-3-hydroxychromone 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 305834-64-4 1-(2-acetoxy-5-methyl-phenyl)-2-chloro-ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 29976-77-0 6-methyl-4'-methoxyflavone 
• 136764-53-9 1a,7a-Dihydro-5-methyl-1a-(4-methoxyphenyl)-7H-oxireno<1>benzopyran-7-one 
• 22307-94-4 2-chloroacetyl-4-methylphenol 
• 123-11-5 4-methoxy-benzaldehyde 
• 75161-61-4 1-(2-acetoxy-5-methyl-phenyl)-2,3-dibromo-3-(4-methoxy-phenyl)-propan-1-one 

Downstream Products

• 109556-83-4 3-acetoxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 807-55-6 3-benzoyloxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 109251-28-7 3-methoxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 1481-81-8 (+/-)-2r-(4-Methoxy-phenyl)-6-methyl-chroman-3c,4c-diol 
• 32766-61-3 4-methoxyphenylglyoxylate methyl ester 
• 78396-40-4 3-(4-Methoxy-phenyl)-6-methyl-3H-isobenzofuran-1-one 
• 964-48-7 (+/-)-cis-2-(4-Methoxy-phenyl)-6-methyl-chroman-3-ol 
• 851-80-9 (+/-)-cis-3-Acetoxy-2-(4-methoxy-phenyl)-6-methyl-chroman 
• 114050-91-8 3-(3-bromo-propoxy)-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 114050-96-3 3-(6-bromo-hexyloxy)-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 

Relevant academic research and scientific papers

Hydroxyl directed: C -arylation: Synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions

An efficient, transition-metal free and direct C-arylation of 3-hydroxychromone moieties in the presence of a base, air as an oxidant and arylhydrazines as arylating agents to furnish highly biologically active flavonols or 3-hydroxyflavones has been developed. We have further extended our methodology for the C-arylation of the 5-hydroxy pyran-4-one moiety. The role of the free hydroxyl group towards C-arylation has been delineated.

Absorption and fluorescent studies of 3-hydroxychromones

The synthesis and spectral studies of variously substituted 3-hydroxychromones have been carried out. A key relationship between the structural motif of synthesized 3-hydroxychromones (3-HCs) and their fluorescent properties was found. The chromones substituted with electron-donating group at 4′-position expressed the red shift of the N and T band and also exhibited the increased fluorescent intensity ratio while the chromones with electron-withdrawing group showed the blue shift of the N and T band. Therefore, these 3-HCs may behave as the possible fluorescent probes.

Epoxidation of Flavones by Dimethyldioxirane

The synthesis of epoxides 2 by epoxidation of flavones 1 with isolated dimethyldioxirane (as acetone solution) at subambient temperatures is reported.These labile epoxides were isolated and completely characterized by UV, IR, 1H and 13C NMR, MS, and C,H analyses.Warming to room temperature led to rearrangement to afford quantitatively the 3-hydroxyflavones 3b,h,i,n.Treatment of the epoxides 2b,f with methanol led to the 3-hydroxy-2-methoxyflavanones 4b,f, as a mixture of cis and trans isomers.