1669-51-8

Basic information

• Product Name: 4'-BROMO-3-PHENYLPROPIOPHENONE
• Synonyms: UKRORGSYN-BB BBV-5118724;4'-BROMO-3-PHENYLPROPIOPHENONE
• CAS NO: 1669-51-8
• Molecular Formula: C₁₅H₁₃BrO
• Molecular Weight: 289.17
• Mol File: 1669-51-8.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 403.8°C at 760 mmHg
• Flash Point: 76.6°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 9.9E-07mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 4'-BROMO-3-PHENYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BROMO-3-PHENYLPROPIOPHENONE(1669-51-8)
• EPA Substance Registry System: 4'-BROMO-3-PHENYLPROPIOPHENONE(1669-51-8)

Safety Data

• Hazardous Substances Data: 1669-51-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H13BrO/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-5,7-10H,6,11H2

Upstream product

• 58824-56-9 1-(p-bromophenyl)prop-2-en-1-ol 
• 98-80-6 phenylboronic acid 
• 99-90-1 para-bromoacetophenone 
• 100-52-7 benzaldehyde 
• 32017-76-8 (+/-)-2-(4-bromophenyl)oxirane 
• 100-51-6 benzyl alcohol 
• 100-42-5 styrene 
• 1122-91-4 4-bromo-benzaldehyde 
• 586-76-5 4-Bromobenzoic acid 
• 873-75-6 4-bromobenzenemethanol 
• 536-74-3 phenylacetylene 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 591-50-4 iodobenzene 
• 766-96-1 4-bromo-1-ethynylbenzene 

Downstream Products

• 43008-85-1 1-(4-bromophenyl)-3-phenylpropane 
• 72758-69-1 (E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one 
• 66648-21-3 3-(p-bromophenyl)indene 
• 742698-54-0 4-(1,1-dimethyl-3-phenyl-propyl)-bromobenzene 
• 113530-93-1 2-Benzyl-3-(4-bromo-phenyl)-1,2-dihydro-quinoxaline 
• 59824-91-8 2-bromo-1-(4-bromophenyl)-3-phenyl-1-propanone 

Relevant articles and documents

Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for α-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Neutral-eosin Y-catalyzed regioselective hydroacylation of aryl alkenes under visible-light irradiation

Styrene derivatives were hydroacylated with exclusive anti-Markovnikov selectivity by using neutral eosin Y as a direct hydrogen-atom-transfer (HAT) catalyst under visible-light irradiation. Aldehydes and styrenes with various substituents were tolerated (>20 examples), giving the corresponding products in moderate to high yields. The key acyl radical intermediate was generated from a direct HAT process induced by photoexcited eosin Y. Subsequent addition to styrenes and a reverse HAT process generated the ketone products.

Borane-Catalyzed, Chemoselective Reduction and Hydrofunctionalization of Enones Enabled by B-O Transborylation

The use of stoichiometric organoborane reductants in organic synthesis is well established. Here these reagents have been rendered catalytic through an isodesmic B-O/B-H transborylation applied in the borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The reaction was found to proceed by a 1,4-hydroboration of the enone and B-O/B-H transborylation with HBpin, enabling catalyst turnover. Single-turnover and isotopic labeling experiments supported the proposed mechanism of catalysis with 1,4-hydroboration and B-O/B-H transborylation as key steps.