16728-67-9

Upstream product

• 954-81-4 N-(5-bromopentyl)phthalimide 
• 108-95-2 phenol 
• 111-24-0 1,5-dibromo-pentane 
• 101890-49-7 2-(5-phenoxypentyl)-1H-isoindole-1,3(2H)-dione 
• 1200-03-9 4-bromophenyl butyl ether 
• 6345-89-7 (3-phenoxypropyl)diethyl propanedioate 
• 63258-09-3 (3-phenoxy-propyl)-malonic acid 
• 7170-40-3 5-phenoxyvaleric acid 
• 3384-04-1 3-chloropropyl phenyl ether 
• 16728-56-6 5-phenoxy-pentanenitrile 

Downstream Products

• 200400-71-1 N-(5-phenoxypentyl)-2-<4-(3-pyridylcarbonyl)phenyl>-4-oxazolecarboxamide 
• 59801-88-6 5-chloropentylamine 
• 362665-16-5 cyclohexyl-(5-phenoxy-pentyl)-amine 
• 87841-94-9 5-Phenoxypentanal 
• 361395-11-1 4,5,6,7-Tetrahydro-1 H-benzimidazole-5-carboxylic acid (5-phenoxypentyl)-amide, Hydrochloride 
• 69325-94-6 (5-phenoxy-pentyl)-quinazolin-4-yl-amine 
• 1350730-45-8 C₃₀H₃₁N₂O₄⁽¹⁺⁾*Cl^(1-) 

Relevant academic research and scientific papers

Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation

A series of 9-N-substituted berberine derivatives were synthesized and biologically evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase and amyloid-β aggregation. Most of these compounds exhibited very good antioxidant activities, inhibitive activities of AChE and amyloid-β aggregation. Among them, compound 8d, (o-methylphenethyl)amino linked at the 9-position of berberine, was found to be a good antioxidant (with 4.05 μM of Trolox equivalents), potent inhibitor of AChE (an IC50 value of 0.027 μM), and high active inhibitor of amyloid-β aggregation (an IC50 value of 2.73 μM).

Imidazole compounds

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.