16735-76-5

Usage

Uses

Used in Pharmaceutical Research:
4-(4-METHOXYBENZYL)-3-THIOSEMICARBAZIDE is used as a chemical intermediate for the synthesis of new drugs with potential antibacterial or antifungal properties. Its unique structure and properties make it a valuable compound for the development of novel therapeutic agents.
Used in Drug Discovery:
In the field of drug discovery, 4-(4-METHOXYBENZYL)-3-THIOSEMICARBAZIDE serves as a promising candidate for the identification and optimization of new lead compounds. Its chemical characteristics and potential biological activities can be further explored to develop innovative treatments for various diseases and conditions.
Used in Medicinal Chemistry:
4-(4-METHOXYBENZYL)-3-THIOSEMICARBAZIDE is utilized in medicinal chemistry for the study of its chemical reactivity, stability, and interactions with biological targets. Understanding these aspects can aid in the design and synthesis of more effective and safer drugs.
Used in Antibacterial Applications:
In the antibacterial industry, 4-(4-METHOXYBENZYL)-3-THIOSEMICARBAZIDE is used as a key component in the development of new antibiotics. Its potential to target and inhibit bacterial growth makes it a valuable asset in the fight against antibiotic-resistant strains.
Used in Antifungal Applications:
Similarly, in the antifungal industry, 4-(4-METHOXYBENZYL)-3-THIOSEMICARBAZIDE is employed for the creation of new antifungal agents. Its ability to combat fungal infections can contribute to the treatment of various fungal diseases and improve patient outcomes.

InChI:InChI=1/C10H14N2OS/c1-11-10(14)12-7-8-3-5-9(13-2)6-4-8/h3-6H,7H2,1-2H3,(H2,11,12,14)

Upstream product

• 105219-33-8 Methyl N-(4-methoxybenzyl)dithiocarbamate 
• 2393-23-9 4-methoxy-benzylamine 
• 75-15-0 carbon disulfide 
• 3694-57-3 1-(isothiocyanatomethyl)-4-methoxybenzene 

Downstream Products

• 95260-21-2 C₂₄H₃₂N₆O₆S₂ 
• 186453-51-0 C₁₆H₁₇N₃O₂S 
• 186453-59-8 C₂₀H₂₆N₄OS 
• 873790-27-3 C₁₀H₁₁N₃OS₂ 

Relevant academic research and scientific papers

Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents

With the aim to combat a multi-faceted neurodegenerative Alzheimer’s disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and biometal chelating activity. Among them, (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(pyridin-2-yl)hydrazinecarbothioamide (62) and (E)-2-((9-ethyl-9H-carbazol-3-yl)methylene)-N-(5-chloropyridin-2-yl)hydrazinecarbothioamide (63) emerged as the premier candidates with good ChE inhibitory activities (IC50 values of 1.37 μM and 1.18 μM for hAChE, IC50 values of 2.69 μM and 3.31 μM for EqBuChE, respectively). All the test compounds displayed excellent antioxidant activity (reduction percentage of DPPH values for compounds (62) and (63) were 85.67% and 84.49%, respectively at 100 μM concentration). Compounds (62) and (63) conferred specific copper ion chelating property in metal chelation study. Molecular docking studies of compounds (62) and (63) indicate strong interactions within the active sites of both the ChE enzymes. Besides that, these compounds also exhibited significant in silico drug-like pharmacokinetic properties. Thus, taken together, they can serve as a starting point in the designing of multifunctional ligands in pursuit of potential anti-AD agents that might further prevent the progression of ADs. Communicated by Ramaswamy H. Sarma.

Synthesis, crystal structure, molecular docking studies and bio-evaluation of some N4-benzyl-substituted isatin-3-thiosemicarbazones as urease and glycation inhibitors

Fifteen N4-benzyl-substituted isatin-3-thiosemicarbazones 5a-o were synthesized and evaluated for their urease and glycation inhibitory potential. Lemna aequinocitalis growth and Artemia salina assays were also done to determine their phytotoxi

Synthesis and in vitro bio-activity evaluation of N4-benzyl substituted 5-chloroisatin- 3-thiosemicarbazones as urease and glycation inhibitors

A series of fifteen N4-benzyl substituted 5-chloroisatin-3-thiosemicarbazones 5a-o were synthesized and screened mainly for their antiurease and antiglycation effects. Lemna aequinocitalis growth and Artemia salina assays were carried out to de

Synthesis, X-ray molecular structure, biological evaluation and molecular docking studies of some N4-benzyl substituted 5-nitroisatin-3-thiosemicarbazones

A series of fifteen N4-benzyl substituted 5-nitroisatin-3-thiosemicarbazones 5a–o was synthesized and evaluated for urease inhibitory, phytotoxic and cytotoxic influences. All the compounds proved to be highly potent inhibitors of the enzyme, s

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identifica