167700-45-0

Upstream product

• 51549-40-7 6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 146578-12-3 5’-O-(4,4’dimethoxytrityl)-N6-(benzoyl)-3’-O-tert-butyldimethylsilyldeoxyadenosine 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 

Downstream Products

• 156100-68-4 (E)-3-[(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-acrylic acid ethyl ester 
• 872131-62-9 (5'S)-N⁵-benzoyl-3'-O-(tert-butyldimethylsilyl)-5'-O-[tris(trimethylsilyl)silyl]-5',8-cyclo-2'-deoxyadenosine 
• 898253-81-1 (5'S,8R)-N-benzoyl-O₃'-(tert-butyldimethylsilyl)-5',8-cyclo-7,8-dihydro-2'-deoxyadenosine 
• 51549-40-7 6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 211919-88-9 (5?'S)-N⁶-benzoyl-3?'-O-(tert-butyldimethylsilyl)-5?',8-cyclo-2?'-deoxyadenosine 
• 583047-57-8 N⁶-benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxy-4'-C-hydroxymethyladenosine 
• 583047-59-0 N⁶-benzoyl-3',5'-di-O-tert-butyldimethylsilyl-4'-C-cyano-2'-deoxyadenosine 
• 583047-58-9 N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 676458-03-0 N⁶-benzoyl-3',5'-di-O-tert-butyldimethylsilyl-4'-C-ethynyl-2'-deoxyadenosine 
• 583047-60-3 N⁶-benzoyl-3',5'-di-O-tert-butyldimethylsilyl-4'-C-cyano-2'-deoxyadenosine 
• 156100-65-1 N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3-oxo-propyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 167080-27-5 N-{9-[(2R,4S,5R)-5-{1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 167080-28-6 N-[9-((2R,4S,5S)-5-{1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide 

Relevant academic research and scientific papers

Radical cyclization approach to cyclonucleosides

Efficient methodologies based on consecutive radical reactions for the preparation of cyclonucleosides 5 and 13 are reported. The reactions were performed on modified thymidine and 2′-deoxyadenosine substrates using (TMS)3SiH as the reducing ag

Design, efficient synthesis, and anti-HIV activity of 4′-C-cyano- and 4′-C-ethynyl-2′-deoxy purine nucleosides

Some 4′-C-ethynyl-2′-deoxy purine nucleosides showed the most potent anti-HIV activity among the series of 4′-C-substituted 2′-deoxynucleosides whose 4′-C-substituents were methyl, ethyl, ethynyl and so on. Our hypothesis is that the smaller the substitue

The synthesis of modified achiral internucleoside linkages: -NHCH2CH2-linked oligonucleosides

A method for the synthesis of oligonucleosides uniformly linked by the NHCH2CH2 moiety is described. Syntheses of heterodimers and a thymidylate trimer along with relevant T and nuclease resistance data are described.