16782-41-5Relevant academic research and scientific papers
Amantadine hapten and preparing method and application thereof
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, (2019/10/01)
The invention relates to the field of preparation of haptens, in particular to an amantadine hapten and a preparing method and application thereof. When the amantadine hapten is prepared, amantadine and bromine polyhydroxyalkanoate serve as raw materials, and through a nucleophilic substitution reaction, amidogen groups in amantadine molecules are connected with the bromine polyhydroxyalkanoate; then through a hydrolysis reaction, carboxyl groups are introduced to obtain a corresponding product. The amantadine hapten can be coupled with a carrier protein to prepare an artificial antigen, the artificial antigen is prepared into a monoclonal antibody or a polyclonal antibody through an immune animal, and then the monoclonal antibody or the polyclonal antibody can be used for quickly detecting residues of the amantadine in an animal product.
ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS
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Paragraph 00141; 00142, (2016/01/01)
Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.
PROCESS FOR PREPARATION OF DPP-IV INHIBITORS
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Page/Page column 23-24, (2011/09/19)
Process for the preparation of DPP-IV inhibitors, such as 1-[[(3-hydroxy-1-adamantyl) amino] acetyl]-2-cyano-(S)-pyrrolidine are disclosed.
BOROLYSINE PEPTIDOMIMETICS
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, (2008/06/13)
Borolysine peptidomimetics of formula I STR1 wherein W, Y, R. sub. 4, R 5, Q 1 and Q 2 are defined in claim 1 are potent thrombin inhibitors.
