169205-93-0

Basic information

• Product Name: N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE
• Synonyms: N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE;N-(3-HYDROXYPYRIDIN-4-YL)PIVALAMIDE;n-(3-hydroxypyridin-4-yl)-2,2-dimethylpropanamide;Zinc04234519
• CAS NO: 169205-93-0
• Molecular Formula: C10H14N2O2
• Molecular Weight: 194.23
• Product Categories: pharmacetical;Amines;Pyridines
• Mol File: 169205-93-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 449.9°Cat760mmHg
• Flash Point: 225.9°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE(169205-93-0)
• EPA Substance Registry System: N-(3-HYDROXY-PYRIDIN-4-YL)-2,2-DIMETHYL-PROPIONAMIDE(169205-93-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 169205-93-0(Hazardous Substances Data)

Usage

General Description

N-(3-Hydroxy-pyridin-4-yl)-2,2-dimethyl-propionamide is a chemical compound also known as HPPD or 4-Hydroxypyridine-2,3-dicarboxylic acid. It is an intermediate in the synthesis of pharmaceuticals and acts as a building block in the production of various compounds. HPPD is a white crystalline powder with a melting point of around 215-217 °C and is sparingly soluble in water. It is used in the synthesis of drugs that target central nervous system disorders and has potential applications in the treatment of neurological and psychiatric conditions. Its chemical structure and properties make it a valuable tool in medicinal chemistry and drug development.

InChI:InChI=1/C10H14N2O2/c1-10(2,3)9(14)12-7-4-5-11-6-8(7)13/h4-6,13H,1-3H3,(H,11,12,14)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 504-24-5 4-aminopyridine 
• 70298-89-4 4-N-pivaloylaminopyridine 

Downstream Products

• 169205-96-3 2-(Methylthio)oxazolo<5,4-c>pyridine 
• 169205-98-5 2-Mercaptooxazolo<5,4-c>pyridine 
• 52334-53-9 4-amino-3-hydroxy pyridine 

Relevant articles and documents

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

In search for a new lead of non-imidazole histamine H3-receptor antagonists, a series of 1[(2-thiazolopyridine)-4-n-propyl]piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl]piperazines, 1-[(2-benzothiazole)-4- n-propyl]piperazine and 1-[(2-benzooxazole)4-n-propyl]piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). It appeared that by comparison of homologous pairs the thiazolo derivatives have slightly higher activity than their oxazolo analogues. The most potent compound of these series is the 1-(2-thiazolo[4,5-c]pyridine)-4-n-propylpiperazine (3c) with pA2 = 7.25 (its oxazole analogue (4g) showed pA2 = 6.9). The structure-activity relationships for compounds with various positions of the nitrogen in the benzene ring for the thiazoles compared with oxazoles are discussed.

Preparation of the four regioisomeric 2-(methylthio)oxazolopyridines: Useful synthons for elaboration to 2-(amino substituted)oxazolopyridines

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