52334-53-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-3-hydroxy pyridine is used as a metabolite for understanding the pharmacokinetics and pharmacodynamics of Fampridine (D113500). As a metabolite, it helps in the study of the drug's metabolism, distribution, and excretion in the body, which is crucial for assessing the drug's safety and efficacy.
Used in Research and Development:
4-AHP is utilized as a research compound in the development of new drugs and therapies. Its structural properties and metabolic relationship with Fampridine make it a valuable tool for scientists to investigate potential applications in various therapeutic areas, including the treatment of neurological disorders.
Used in Quality Control and Analysis:
In the pharmaceutical industry, 4-Amino-3-hydroxy pyridine is used as a reference compound for quality control and analytical purposes. It helps in the identification, quantification, and purity assessment of Fampridine and its related compounds, ensuring the consistency and quality of the drug products.
Used in Drug Metabolism Studies:
4-AHP serves as an essential compound in drug metabolism studies, providing insights into the metabolic pathways and potential drug-drug interactions involving Fampridine. This information is vital for the development of safer and more effective drug therapies.

InChI:InChI=1/C5H6N2O/c6-4-1-2-7-3-5(4)8/h1-3,8H,(H2,6,7)

Upstream product

• 142222-73-9 4-amino-3-pyridyl N,N-diethylcarbamate 
• 51581-40-9 3-pyridyl diethylcarbamate 
• 52334-90-4 4-amino-3-methoxy pyridine 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 504-24-5 4-aminopyridine 
• 169205-93-0 3-Hydroxy-4-(pivalolylamino)pyridine 
• 100130-15-2 3-hydroxy-4-aminopyridine sulfate 

Downstream Products

• 121991-46-6 N-(3-benzoyloxy-[4]pyridyl)-dibenzamide 
• 169205-98-5 2-Mercaptooxazolo<5,4-c>pyridine 
• 169205-96-3 2-(Methylthio)oxazolo<5,4-c>pyridine 
• 142222-57-9 N-Cyclohexyl-N'-(3-hydroxy-pyridin-4-yl)-N-methyl-formamidine 
• 143164-02-7 N-Benzyl-N'-(3-hydroxy-pyridin-4-yl)-N-methyl-formamidine 
• 142222-62-6 Phenyl-carbamic acid 4-(dimethylamino-methyleneamino)-pyridin-3-yl ester 
• 142222-90-0 Dimethyl-carbamic acid 4-[(cyclohexyl-methyl-amino)-methyleneamino]-pyridin-3-yl ester 
• 142222-92-2 Dimethyl-carbamic acid 4-[(benzyl-methyl-amino)-methyleneamino]-pyridin-3-yl ester 
• 194022-44-1 1H-Pyrido[3,4-b][1,4]oxazine-2-(3H)one 
• 68523-29-5 1H-oxazolo[5,4-c]pyridin-2-one 

Relevant academic research and scientific papers

HETEROCYCLIC DERIVATIVES

The present invention relates to heterocyclic derivatives, and more particularly, to novel heterocyclic derivatives useful for the preparation of medicaments for treating diseases related to uric acid.

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

In search for a new lead of non-imidazole histamine H3-receptor antagonists, a series of 1[(2-thiazolopyridine)-4-n-propyl]piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl]piperazines, 1-[(2-benzothiazole)-4- n-propyl]piperazine and 1-[(2-benzooxazole)4-n-propyl]piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). It appeared that by comparison of homologous pairs the thiazolo derivatives have slightly higher activity than their oxazolo analogues. The most potent compound of these series is the 1-(2-thiazolo[4,5-c]pyridine)-4-n-propylpiperazine (3c) with pA2 = 7.25 (its oxazole analogue (4g) showed pA2 = 6.9). The structure-activity relationships for compounds with various positions of the nitrogen in the benzene ring for the thiazoles compared with oxazoles are discussed.

Aminopyridine carbamic acid esters: Synthesis and potential as acetylcholinesterase inhibitors and acetylcholine releasers

4-Amino-3-pyridyl carbamates (2a-c) were synthesized as potential acetylcholinesterase inhibitors and acetylcholine releasers on the basis of the reported activity of the analogous N-(4-amino-3-pyridyl)-N',N'- dimethylurea (1). Although 4-amino-3-pyridyl N,N-dimethylcarbamate (2b) showed good cholinesterase inhibition [concentration that elicited a 50% reduction in the maximal enzyme response (IC50) was 13.4 μM], it had no effect on the stimulated release of [3H]acetylcholine from rat striatal slices. 4-[[(Dimethylamino)methylene]amino]-3-pyridyl N,N-dimethylcarbamate (7a), an intermediate in the synthesis of 2b, demonstrated surprisingly good cholinesterase inhibition (IC50 was 9.4 μM) but showed no activity as a releaser. A precursor to 7a, N-(3-hydroxy-4-pyridyl)-N',N'- dimethylformamidine (6a), showed some activity in release but was not an esterase inhibitor, whereas the precursor to 6a, 4-amino-3-pyridinol (5a), was a potent releaser. A new synthesis of 5a, based on an ortho-directed lithiation strategy, is also reported.