169295-49-2

Upstream product

• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 
• 6285-05-8 4'-chloropropiophenone 
• 64-19-7 acetic acid 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 90919-32-7 α-methoxy-p-chloropropiophenone 
• 127-08-2 potassium acetate 
• 1026945-81-2 4-Nitro-benzenesulfonic acid 2-(4-chloro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 49656-24-8 1-(4-chlorophenyl)-2-hydroxypropan-1-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 151716-73-3 (R)-(+)-1-(4-chlorophenyl)-2-hydroxypropan-1-one 
• 99187-99-2 2-(4-chlorophenyl)butane-2,3-diol 

Relevant academic research and scientific papers

METHOD FOR PRODUCING ALPHA-ACYLOXYCARBONYL COMPOUND AND NOVEL ALPHA-ACYLOXYCARBONYL COMPOUND

A method for producing an α-acyloxycarbonyl compound of the present invention includes performing an intermolecular reaction between a carboxylic acid and a carbonyl compound selected from the group consisting of ketones, aldehydes, and esters, which have

Redox catalysis of halide ion for formal cross-dehydrogenative coupling: Bromide ion-catalyzed direct oxidative α-acetoxylation of ketones

A novel catalytic approach for formal cross-dehydrogenative coupling using the redox property of bromide ion is reported. Simple bromide salts MBr can work as catalyst for direct oxidative α-acetoxylation of ketones.

A facile synthesis of secondary α-alkoxy or α-acetoxy aromatic ketones

The treatment of HNIB with aromatic ketones and subsequent solvolysis using alcohol or acetic acid in one-pot system makes it possible to give corresponding secondary α-alkoxy or α-acetoxy ketones in high yields.

Resolution of Secondary α-Ketoalcohols Catalyzed by Lipase and Inversioon of Stereochemistry

Several α-ketoalcohols of synthetic value were resolved using lipase as a catalyst.Lipoprotein lipase (LPL) provided the best rate of hydrolysis and kinetic differentiation.One of these optically pure α-ketoalcohol was converted to (S)-ibuprofen in good optical purity.The stereospecific inversion of (R)-alcohol to (S)-alcohol is described.Key Words Enzymatic resolution; α-Ketoalcohol; (S)-Ibuprofen

Enzymes in Organic Synthesis: Lipase Catalyzed Resolution of Secondary α-Ketoalcohols

Resolution of several α-ketoalcohols of synthetic value using lipase as a catalyst is described.