169512-94-1

Basic information

• Product Name: (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester
• Synonyms: (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester
• CAS NO: 169512-94-1
• Molecular Weight: 265.309
• Mol File: 169512-94-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester(169512-94-1)
• EPA Substance Registry System: (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester(169512-94-1)

Safety Data

• Hazardous Substances Data: 169512-94-1(Hazardous Substances Data)

Usage

General Description

(+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester is a chemical compound that is composed of the α-phenylglycine and methyl ester functional groups. It is often used as a reagent in chemical synthesis, particularly in the production of pharmaceuticals and other organic compounds. The N-tert-butoxycarbonyl (Boc) group is a protective group commonly used in organic synthesis to prevent unwanted reactions at specific functional groups on molecules. The Boc-α-phenylglycine methyl ester compound is often employed as an intermediate in the synthesis of various pharmaceuticals and complex organic molecules. It is important to handle this compound with care, as it is a potentially hazardous chemical that can cause irritation and other adverse effects if not used properly.

Upstream product

• 124-38-9 carbon dioxide 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 74-88-4 methyl iodide 
• 2835-06-5 phenylglycin 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 4248-19-5 tert-butyl carbazate 
• 100-52-7 benzaldehyde 
• 2900-27-8 2-(tert-butoxycarbonylamino)-2-phenylacetic acid 
• 1273585-69-5 (butyl)3SnCH(phenyl)NH(tert-butoxycarbonyl) 
• 22979-35-7 Methyl phenyldiazoacetate 
• 1334313-47-1 (Z)-methyl 2-phenyl-2-(2-tosylhydrazono)acetate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 150884-50-7 benzaldehyde N-boc imine 

Downstream Products

• 140196-38-9 1,1-dimethyl (2-oxo-1-phenylethyl)carbamate 
• 24461-61-8 phenylglycine methyl ester 
• 869563-40-6 (4S)-4-benzyl-3-(2-methylpropionyl)-2-oxazolidinone 
• 170918-42-0 (R)-(-)-5,5-dimethyl-4-phenyl-2-oxazolidinone 
• 168297-84-5 (4S)-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 86217-38-1 4-phenyl-2-oxazolidinone 
• 33664-93-6 5,5-dimethyl-4-phenyl-oxazolidin-2-one 

Relevant articles and documents

Synthesis ofN-Boc-α-amino Acids from Carbon Dioxide by Electrochemical Carboxylation ofN-Boc-α-aminosulfones

Electrochemical reduction ofN-Boc-α-aminosulfones in DMF using an undivided cell equipped with a Pt plate cathode and an Mg rod anode under atmospheric pressure of bubbling carbon dioxide through the solution under constant current conditions resulted in a reductive C-S bond cleavage with elimination of benzenesulfinate ion generating the corresponding anion species followed by fixation of carbon dioxide to give the correspondingN-Boc-α-amino acids in moderate to good yields.

Tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity and chemoselectivity of this novel Boc reagent. The reaction was carried out chemoselectively in high yield under mild, environment-friendly conditions and was completed quickly within 1 hour. Simultaneously, the Boc carrier was easily recyclable, and has great application prospects for industrial production.

N—H Insertion Reactions Catalyzed by a Dirhodium Metal-Organic Cage: A Facile and Recyclable Approach for C—N Bond Formation

A heterogeneous metal-organic cage based on Rh-Rh bonds [Rh4(pbeddb)4(H2O)2(DMAC)2] (MOC-18; pbeddb2? = 3,3'-(1,3-phenylenebis(ethyne-2,1-diyl))dibenzoate) was applied to the N—H insertion