169616-07-3

Basic information

• Product Name: dimethyl 1-benzyl-3,4-diethoxypyrrole-2,5-dicarboxylate
• Synonyms: dimethyl 1-benzyl-3,4-diethoxypyrrole-2,5-dicarboxylate
• CAS NO: 169616-07-3
• Molecular Weight: 361.395
• Mol File: 169616-07-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl 1-benzyl-3,4-diethoxypyrrole-2,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 1-benzyl-3,4-diethoxypyrrole-2,5-dicarboxylate(169616-07-3)
• EPA Substance Registry System: dimethyl 1-benzyl-3,4-diethoxypyrrole-2,5-dicarboxylate(169616-07-3)

Safety Data

• Hazardous Substances Data: 169616-07-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 6175-26-4 dimethyl 2,2′-(benzylazanediyl)diacetate 
• 1632-19-5 dimethyl 3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate 
• 6096-81-7 dimethyl iminodiacetate 
• 64-67-5 diethyl sulfate 
• 148528-45-4 dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate 

Downstream Products

• 169616-16-4 3,4-diethoxy-1H-pyrrole 

Relevant articles and documents

3,4-Dialkoxypyrroles and 2,3,7,8,12,13,17,18-octaalkoxyporphyrins

A five-step general synthesis of 3,4-dialkoxypyrroles 7c-f is described starting with the condensation of dimethyl N-benzyliminodiacetate (1 b) and diethyl oxalate to give dimethyl 1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (2b), which is bis-O-alkylated to the corresponding 3,4-diethers 3c-g. Pyrrole N-benzyl cleavage followed by ester hydrolysis and decarboxylation leads to 7c-f in 10-50% overall yield. Pyrroles 7c-f react with formaldehyde or benzaldehydes to give meso-H- (8a-d) or meso-tetraaryloctaalkoxyporphyrins 9a-g in moderate yields.