170456-59-4

Upstream product

• 367-27-1 2,4-difluorophenol 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 

Downstream Products

• 170456-60-7 S-(2,4-difluorophenyl)dimethylthiocarbamate 
• 1996-44-7 2,4-difluorothiophenol 
• 158205-23-3 5-amino-6-<(2,4-difluorophenyl)thio>-1-indanone 
• 158205-05-1 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone 
• 158205-22-2 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal 
• 170456-58-3 5--6-(2,4-difluorophenylthio)-1-indanone 

Relevant academic research and scientific papers

Synthesis of 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone

The ethylene ketal of 5-nitro-6-bromo-1-indanone 6 was prepared via oxidation of N-(6-Bromo-5-indanyl)-acetamide 1. A subsequent mild displacement and elaboration to 6-thiosubstituted-5-amino indanone derivative 10 is also described.

A high temperature investigation using microwave synthesis for electronically and sterically disfavoured substrates of the Newman-Kwart rearrangement

Electronically deactivated and/or sterically hindered substrates undergo the Newman-Kwart rearrangement (NKR) at around 300 °C, beyond the range of most convenient and safe, small-scale laboratory equipment. We report here the convenient conversions of several difficult substrates using modern microwave technology, which has proven ideal for investigating this high temperature reaction in all but the?most refractory of cases. In addition, several previously reported difficult examples were re-investigated, and found not to require high temperatures under these conditions, for various reasons which are elaborated upon.