158205-05-1Relevant articles and documents
Method for the treatment and prevention of cachexia
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, (2008/06/13)
Cachexia, including anorexia and other forms of weight loss, is a frequent complication of acute and chronic infections, and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. The present invention includes methods for the treatment or prevention of cachexic conditions while maintaining the production of factors essential for infection control through the administration of an effective amount of a cyclooxygenase-2 selective inhibiting compound.
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
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, (2008/06/13)
The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.
Synthesis of 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone
Scheigetz,Zamboni,Roy
, p. 2791 - 2806 (2007/10/02)
The ethylene ketal of 5-nitro-6-bromo-1-indanone 6 was prepared via oxidation of N-(6-Bromo-5-indanyl)-acetamide 1. A subsequent mild displacement and elaboration to 6-thiosubstituted-5-amino indanone derivative 10 is also described.