158205-22-2

Basic information

• Product Name: 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal
• Synonyms: 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal
• CAS NO: 158205-22-2
• Molecular Weight: 365.357
• Mol File: 158205-22-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal(CAS DataBase Reference)
• NIST Chemistry Reference: 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal(158205-22-2)
• EPA Substance Registry System: 6-<(2,4-difluorophenyl)thio>-5-nitro-1-indanone ethylene ketal(158205-22-2)

Safety Data

• Hazardous Substances Data: 158205-22-2(Hazardous Substances Data)

Upstream product

• 1996-44-7 2,4-difluorothiophenol 
• 158205-21-1 5-nitro-6-bromo-1-indanone ethylene ketal 
• 170456-60-7 S-(2,4-difluorophenyl)dimethylthiocarbamate 
• 170456-59-4 O-(2,4-difluorophenyl)dimethylthiocarbamate 
• 367-27-1 2,4-difluorophenol 
• 158205-18-6 5-Acetylamino-6-bromo-1-indanone 
• 158205-20-0 5-nitro-6-bromo-1-indanone 
• 158205-19-7 5-Amino-6-bromo-1-indanone 
• 59856-06-3 5-acetamidoindane 
• 157701-33-2 5-acetylamino-6-bromoindane 
• 24425-40-9 indan-5-amine 

Downstream Products

• 158205-05-1 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone 
• 170456-58-3 5--6-(2,4-difluorophenylthio)-1-indanone 
• 158205-23-3 5-amino-6-<(2,4-difluorophenyl)thio>-1-indanone 

Relevant articles and documents

5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2

The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.

Synthesis of 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone

The ethylene ketal of 5-nitro-6-bromo-1-indanone 6 was prepared via oxidation of N-(6-Bromo-5-indanyl)-acetamide 1. A subsequent mild displacement and elaboration to 6-thiosubstituted-5-amino indanone derivative 10 is also described.