158205-22-2

Upstream product

• 367-27-1 2,4-difluorophenol 
• 1996-44-7 2,4-difluorothiophenol 
• 158205-21-1 5-nitro-6-bromo-1-indanone ethylene ketal 
• 170456-60-7 S-(2,4-difluorophenyl)dimethylthiocarbamate 
• 170456-59-4 O-(2,4-difluorophenyl)dimethylthiocarbamate 
• 158205-18-6 5-Acetylamino-6-bromo-1-indanone 
• 158205-20-0 5-nitro-6-bromo-1-indanone 
• 158205-19-7 5-Amino-6-bromo-1-indanone 
• 59856-06-3 5-acetamidoindane 
• 157701-33-2 5-acetylamino-6-bromoindane 
• 24425-40-9 indan-5-amine 

Downstream Products

• 158205-23-3 5-amino-6-<(2,4-difluorophenyl)thio>-1-indanone 
• 170456-58-3 5--6-(2,4-difluorophenylthio)-1-indanone 
• 158205-05-1 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone 

Relevant academic research and scientific papers

5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2

The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.

Synthesis of 5-methanesulfonamido-6-(2,4-difluorophenylthio)-1-indanone

The ethylene ketal of 5-nitro-6-bromo-1-indanone 6 was prepared via oxidation of N-(6-Bromo-5-indanyl)-acetamide 1. A subsequent mild displacement and elaboration to 6-thiosubstituted-5-amino indanone derivative 10 is also described.

Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives

The recent discovery of an alternative form cyclooxygenase (cyclooxygenase-2, COX-2), which has been proposed to play a significant role in inflammatory conditions, may provide an opportunity to develop anti- inflammatory drugs with fewer side effects tha