170464-72-9Relevant academic research and scientific papers
Synthesis of 7H-tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines and their reductive ring cleavage to 4-aminopyrrolo[2,3-d]pyrimidines
Dave, Chaitanya G.,Shah, Rina D.
, p. 1295 - 1300 (2007/10/03)
Some new 7,9-disubstituted 7H-1,2,3,4-tetrazolo[1,5-c]pyrrolo[3,2- e]pyrimidines 5 have been synthesized either by diazotization of 4-hydrazino- 5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 4 obtained by hydrazinolysis of 4-chloro-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 3 or via a substitution reaction between 3 and sodium azide. 5,7-Disubstituted-7H- pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were obtained by cyclocondensation of 2- amino-3-cyano-1,4-disubstituted pyrroles 1 with formic acid which on chlorination using phosphorus oxychloride afforded 3. A novel route for the synthesis of 4-amino-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 6 by the reductive ring cleavage of 5 has been reported.
PYRROLOPYRIMIDIMES. I: Synthesis of Novel Pyrrolopyrimidine Derivatives With Antimicrobial Activity
El-Bayouki, Khairy A. M.,Basyouni, Wahid M.,Hosni, H.,El-Deen, A. Shehab
, p. 1901 - 1912 (2007/10/02)
The preparation and cyclization of 2-aminopyrrole-3-carbonitriles 3 to the corresponding pyrrolopyrimidin-4-ones 5 were carriedout.The products 5 with phosphoryl chloride gave 4-chloropyrrolopyrimidine derivatives 7, which when reacted with hydrazine hydrate gave the corresponding 4-hydrazinopyrrolopyrimidines 8 in excellent yield.The syntheses of triazolo-9, tetrazolo-10 and 4-(3,5-dimethylpyrazolo)-12 pyrrolopyrimidines, as well as of a 3-(pyrrolopyrimidynylhydrazono)butanoate ester 13, are also reported.Selected examples from the newly synthesized compounds were tested in vitro for their antimicrobial activity.
