170464-79-6

Upstream product

• 64-18-6 formic acid 
• 115998-21-5 2-amino-4-(4-chlorophenyl)-1-(p-tolyl)pyrrole-3-carbonitrile 
• 60532-55-0 1-(4-chloro-phenyl)-2-p-toluidino-ethanone 

Downstream Products

• 170464-72-9 9-(4-chlorphenyl)-7-(p-tolyl)-7H-pyrrolo<3,2-e>tetrazolo<1,5-c>pyrimidine 
• 170464-83-2 [5-(4-Chloro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 115998-31-7 5-(4-Chloro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 
• 170464-81-0 4-Chloro-5-(4-chloro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Synthesis of 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones and their N-alkylation's under phase transfer conditions

5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were synthesized by the cyclocondensation of 1,4-disubstituted 2-amino-3-cyanopyrrole 1 with formic acid. When comparative study of N versus O alkylation of ambident 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 was carried out under liquid-liquid PTC, solid-liquid PTC, and solid-liquid solvent free conditions using various alkylating agents 3, the N-alkylated product 4 were obtained selectively and exclusively.

Synthesis of 7H-tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines and their reductive ring cleavage to 4-aminopyrrolo[2,3-d]pyrimidines

Some new 7,9-disubstituted 7H-1,2,3,4-tetrazolo[1,5-c]pyrrolo[3,2- e]pyrimidines 5 have been synthesized either by diazotization of 4-hydrazino- 5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 4 obtained by hydrazinolysis of 4-chloro-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 3 or via a substitution reaction between 3 and sodium azide. 5,7-Disubstituted-7H- pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were obtained by cyclocondensation of 2- amino-3-cyano-1,4-disubstituted pyrroles 1 with formic acid which on chlorination using phosphorus oxychloride afforded 3. A novel route for the synthesis of 4-amino-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 6 by the reductive ring cleavage of 5 has been reported.

PYRROLOPYRIMIDIMES. I: Synthesis of Novel Pyrrolopyrimidine Derivatives With Antimicrobial Activity

The preparation and cyclization of 2-aminopyrrole-3-carbonitriles 3 to the corresponding pyrrolopyrimidin-4-ones 5 were carriedout.The products 5 with phosphoryl chloride gave 4-chloropyrrolopyrimidine derivatives 7, which when reacted with hydrazine hydrate gave the corresponding 4-hydrazinopyrrolopyrimidines 8 in excellent yield.The syntheses of triazolo-9, tetrazolo-10 and 4-(3,5-dimethylpyrazolo)-12 pyrrolopyrimidines, as well as of a 3-(pyrrolopyrimidynylhydrazono)butanoate ester 13, are also reported.Selected examples from the newly synthesized compounds were tested in vitro for their antimicrobial activity.