17087-75-1

Basic information

• Product Name: (2S,3S)-2,3-Epoxysuccinic acid
• Synonyms: (2S,3S)-2,3-Epoxysuccinic acid;(2α,3β)-2,3-Oxiranedicarboxylic acid;[2S,3S,(+)]-2,3-Oxiranedicarboxylic acid;Ep-0;trans-Ethyleneoxidedicarboxylic acid;(2S,3S)-oxirane-2,3-dicarboxylic acid
• CAS NO: 17087-75-1
• Molecular Formula: C₄H₄O₅
• Molecular Weight: 132.07
• Mol File: 17087-75-1.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• PKA: pK1:1.93;pK2:3.25 (25°C)
• CAS DataBase Reference: (2S,3S)-2,3-Epoxysuccinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-2,3-Epoxysuccinic acid(17087-75-1)
• EPA Substance Registry System: (2S,3S)-2,3-Epoxysuccinic acid(17087-75-1)

Safety Data

• Hazardous Substances Data: 17087-75-1(Hazardous Substances Data)

Upstream product

• 141-36-6 DL-trans-epoxysuccinic acid 
• 110-17-8 (2E)-but-2-enedioic acid 
• 17087-75-1 (-)-trans-2,3-oxiranedicarboxylic acid 
• 17015-08-6 (2R,3R)-oxirane-2,3-dicarboxylic acid 
• 75-91-2 tert.-butylhydroperoxide 
• 624-49-7 dimethylfumarate 
• 3291-46-1 (2SR,3SR)-oxirane-2,3-dicarboxylic acid diethyl ester 
• 3291-46-1 (2S,3S)-diethyl oxirane-2,3-dicarboxylate 
• 3272-11-5 2,3-oxiranedicarboxylic acid 
• 165877-67-8 (+)(2R:3R)-3-chloro-2-hydroxy-succinic acid 

Downstream Products

• 141-36-6 DL-trans-epoxysuccinic acid 
• 17087-75-1 (-)-trans-2,3-oxiranedicarboxylic acid 
• 17015-08-6 (2R,3R)-oxirane-2,3-dicarboxylic acid 
• 6463-75-8 N-(DL-α-Methyl-benzyl)-erythro-β-hydroxy-DL-asparaginsaeure 
• 1186-90-9 erythro-β-hydroxy-DL-aspartic acid 
• 3291-46-1 (2S,3S)-diethyl oxirane-2,3-dicarboxylate 
• 133-37-9 DL-tartaric acid 
• 87-69-4 tartaric acid 
• 75-07-0 acetaldehyde 
• 22734-81-2 trans-epoxysuccinyl chloride 
• 16417-32-6 N-benzyl-erythro-β-hydroxy-DL-aspartic acid 
• 1631180-15-8 C₂₆H₃₈N₆O₁₁ 
• 3291-46-1 (2SR,3SR)-oxirane-2,3-dicarboxylic acid diethyl ester 
• 646532-92-5 (2S,3S)-oxirane-2,3-dicarboxylic acid monobenzyl ester 

Relevant articles and documents

2,3-EPOXY SUCCINYL DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF

The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or

2, 3-Butanediamide Epoxide Compound and Preparation Method and Use Thereof

Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.

Design, synthesis, and screen of cathepsin K inhibitors

We synthesized a series of epoxysuccinic acid derivatives and evaluated their in vitro cathepsin K inhibitory activity The screening results show that the potency of compounds 9e, 9d, 9p, 9j and 9k (IC50 ≤ 0.005 μmol/L) were equal to or greater than that of the lead compound 9a. Less hydrophobic compounds showed weaker potency, which can be explained by the hydrophobic nature of the cathepsin K binding pockets.