1711-88-2

Usage

Uses

Used in Pharmaceutical Synthesis:
5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and reactivity make it a valuable component in the development of new medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE is utilized as an intermediate for the production of agrochemicals. Its properties contribute to the formulation of effective products for agricultural applications.
Used in Specialty Chemicals:
5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE is used as a building block in the preparation of specialty chemicals, where its chemical properties are leveraged to create unique and specific compounds for various applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE is used as a research compound to explore its pharmacological properties. Its potential applications in drug discovery are being investigated, with the aim of identifying new therapeutic agents.
Note: Since the provided materials do not specify particular applications or industries for 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE, the uses listed are general and based on the compound's described properties and typical applications of similar intermediates in various industries.

InChI:InChI=1/C5H8N2O2/c1-3(2)4-6-7-5(8)9-4/h3H,1-2H3,(H,7,8)

Upstream product

• 75-44-5 phosgene 
• 79-31-2 isobutyric Acid 
• 3619-17-8 isobutyric acid hydrazide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 546-68-9 titanium(IV) isopropylate 

Downstream Products

• 96240-10-7 4-amino-3-isopropyl-1H-1,2,4-triazol-5-(4H)-one 
• 1351342-61-4 ((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

C5A RECEPTOR MODULATORS

The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES

The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are The present invention discloses derivatives of formula (I), wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, and in particular e.g. 2,4,6,7-tetrahydro-pyrazolo[4,3- d]pyrimidin-5-one derivatives and related compounds, their preparation, pharmaceutically acceptable salts thereof, their use as pharmaceuticals, pharmaceutical compositions containing one or more compounds of formula (I), and especially their use as C5a receptor modulators for treating e.g. vasculitis and inflammatory diseases.

Amicarbazone synthesis method

The invention discloses an amicarbazone synthesis method, which comprises: synthesizing tert-butyl isocyanate; synthesizing 5-methyl-1,3,4-oxadiazol-2(3H)-one; synthesizing 4-amino-3-isopropyl-5-oxo-1-H-1,2,4-triazole (triazolinone); adding hydrazine hydrate and a second NaOH solution to a third reactor, uniformly stirring, heating to a temperature of 90-100 DEG C, adding the prepared 5-methyl-1,3,4-oxadiazol-2(3H)-one in a dropwise manner, carrying out a reaction after completing the adding, cooling to a room temperature, adding a second solvent, adjusting the pH value to a neutral pH value, freezing for 2-2.5 h, filtering, washing the filter cake, re-crystallizing, and drying to obtain triazolinone; and synthesizing the amicarbazone, wherein triazolinone, potassium hydroxide, a second catalyst and a third solvent are added to a fourth reactor, the prepared tert-butyl isocyanate is added in a dropwise manner, and a heating reaction is performed to obtain the amicarbazone. According to the present invention, the synthesis method has advantages of mild reaction conditions, no requirement of special equipment, good economy, high total yield and good industrial prospect.

Process for preparing substituted oxadiazolones

Substituted oxadiazolones of the formula (I) STR1 in which R represents optionally substituted alkyl, are obtained in good yields and high purity on reacting in a first step carboxylic acids of the general formula (II) with hydrazine hydrate in the presen