1711-88-2

Basic information

• Product Name: 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE
• Synonyms: 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE;5-(propan-2-yl)-2,3-dihydro-1,3,4-oxadiazol-2-one
• CAS NO: 1711-88-2
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.13
• Mol File: 1711-88-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.33g/cm³
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE(1711-88-2)
• EPA Substance Registry System: 5-(1-METHYLETHYL)-1,3,4-OXADIAZOL-2(3H)-ONE(1711-88-2)

Safety Data

• Hazardous Substances Data: 1711-88-2(Hazardous Substances Data)

Usage

General Description

5-(1-Methylethyl)-1,3,4-oxadiazol-2(3H)-one, also known as PMEO, is a chemical compound with the molecular formula C6H10N2O2. It is a white to off-white crystalline powder that is soluble in polar organic solvents. PMEO is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as a building block for the preparation of various heterocyclic compounds. Additionally, PMEO has potential applications in the field of medicinal chemistry due to its pharmacological properties. However, further research is needed to fully understand its potential uses and effects.

InChI:InChI=1/C5H8N2O2/c1-3(2)4-6-7-5(8)9-4/h3H,1-2H3,(H,7,8)

Upstream product

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Downstream Products

• 96240-10-7 4-amino-3-isopropyl-1H-1,2,4-triazol-5-(4H)-one 
• 1351342-61-4 ((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(5-isopropyl-[1,3,4]oxadiazol-2-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester 

Relevant articles and documents

C5A RECEPTOR MODULATORS

The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

Amicarbazone synthesis method

The invention discloses an amicarbazone synthesis method, which comprises: synthesizing tert-butyl isocyanate; synthesizing 5-methyl-1,3,4-oxadiazol-2(3H)-one; synthesizing 4-amino-3-isopropyl-5-oxo-1-H-1,2,4-triazole (triazolinone); adding hydrazine hydrate and a second NaOH solution to a third reactor, uniformly stirring, heating to a temperature of 90-100 DEG C, adding the prepared 5-methyl-1,3,4-oxadiazol-2(3H)-one in a dropwise manner, carrying out a reaction after completing the adding, cooling to a room temperature, adding a second solvent, adjusting the pH value to a neutral pH value, freezing for 2-2.5 h, filtering, washing the filter cake, re-crystallizing, and drying to obtain triazolinone; and synthesizing the amicarbazone, wherein triazolinone, potassium hydroxide, a second catalyst and a third solvent are added to a fourth reactor, the prepared tert-butyl isocyanate is added in a dropwise manner, and a heating reaction is performed to obtain the amicarbazone. According to the present invention, the synthesis method has advantages of mild reaction conditions, no requirement of special equipment, good economy, high total yield and good industrial prospect.