171285-25-9

Upstream product

• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 105-53-3 diethyl malonate 
• 171285-26-0 diethyl 2-hydroxymethyl-2-(4,4'-dimethoxytrityloxymethyl)malonate 

Relevant academic research and scientific papers

A New Approach for Chemical Phosphorylation of Oligonucleotides at the 5'-Terminus

A new efficient method for chemical 5'-phosphorylation of synthetic oligonucleotides is described.Accordingly, 2-cyanoethyl 3-(4,4'-dimethoxytrityloxy)-2,2-di(ethoxycarbonyl)propyl-1 N,N-diisopropyl phosphoramidite (1) was introduced as the 5'-terminal bu

Synthesis of Oligonucleotide Analogues by Using Phosphoramidite Reagents Derived from 2,2-Bis(hydroxymethyl)malonates

A new family of non-nucleosidic phosphoramidite reagents derived from either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is described.The utility of the building blocks 1-5 is demonstrated by preparation of 5'-phosphorylated oligonucleotides as well as hydrophobic, polyamino and fluorescent labelled oligonucleotide analogues.