A New Approach for Chemical Phosphorylation of Oligonucleotides at the 5'-Terminus

DOI: 10.1016/0040-4020(95)00544-I

Source and publish data:

Tetrahedron p. 9375 - 9384 (1995)

Update date:2022-08-03

Topics:

Authors:

Guzaev, Andrei

Salo, Harri

Azhayev, Alex

Loennberg, Harri

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Article abstract of DOI:10.1016/0040-4020(95)00544-I

A new efficient method for chemical 5'-phosphorylation of synthetic oligonucleotides is described.Accordingly, 2-cyanoethyl 3-(4,4'-dimethoxytrityloxy)-2,2-di(ethoxycarbonyl)propyl-1 N,N-diisopropyl phosphoramidite (1) was introduced as the 5'-terminal bu

Full text of DOI:10.1016/0040-4020(95)00544-I

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