17129-06-5

Usage

Uses

Used in Chemical Synthesis:
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one is used as a synthetic intermediate for the production of various organic compounds. It is particularly useful for the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones and β-alkylor dialkylamino substituted enones bearing a CF3 group, which are important building blocks in the development of pharmaceuticals and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one is used as a key component in the synthesis of complex molecular structures with potential therapeutic applications. Its ability to form N-protected amino acids makes it a valuable asset in the development of new drugs and drug candidates.
Used in Material Science:
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may also find applications in material science, particularly in the development of novel materials with specific properties, such as enhanced stability or reactivity, due to the presence of the trifluoromethyl group.
Used in Research and Development:
In the field of research and development, 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one serves as a versatile compound for exploring new reaction pathways and understanding the fundamental chemistry of organofluorine compounds. Its unique reactivity with various reagents makes it an attractive candidate for studying reaction mechanisms and developing new synthetic methodologies.

InChI:InChI=1/C8H7BrFNO/c1-11-8(12)6-4-5(10)2-3-7(6)9/h2-4H,1H3,(H,11,12)

Upstream product

• 109-92-2 ethyl vinyl ether 
• 407-25-0 trifluoroacetic anhydride 
• 17128-99-3 2-(difluoro-nitro-methyl)-4-ethoxy-2-trifluoromethyl-oxetane 
• 354-32-5 trifluoracetyl chloride 
• 1095142-49-6 4-chloro-4-ethoxy-1,1,1-trifluoro-3-butan-2-one 
• 354-34-7 trifluoroacetyl fluoride 
• 109-93-3 1,1'-oxybisethene 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 109-94-4 formic acid ethyl ester 
• 76-05-1 trifluoroacetic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 400-36-2 trifluoroacetylacetic acid 
• 17129-03-2 4-ethoxy-1,1-difluoro-1-nitro-2-trifluoromethyl-but-3-en-2-ol 

Downstream Products

• 142991-64-8 (Z)-1,1,1-Trifluoro-4-(2-oxo-2-phenyl-ethylamino)-but-3-en-2-one 
• 538308-78-0 4-(ethylamino)-1,1,1-trifluoro-3-buten-2-one 
• 142991-63-7 Phenyl-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-acetic acid ethyl ester 
• 136547-18-7 4-trifluoromethyl-2-N-(4-N'-acetylaminophenylsulfo)aminopyrimidine 
• 120417-45-0 4-amino-1,1,1-trifluoro-3-butene-2-one 
• 136547-16-5 4-(trifluoromethyl)pyrimidine 
• 21045-62-5 4-(diethylamino)-1,1,1-trifluorobut-3-en-2-one 
• 176722-51-3 4-anilino-1,1,1-trifluorobut-3-en-2-one 
• 101966-56-7 (Z)-1,1,1-Trifluoro-4-[2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-phenylamino]-but-3-en-2-one 
• 104048-92-2 4-(trifluoromethyl)-2-pyrimidinol 
• 121310-78-9 1,1,1-trifluoro-4-methylphenylamino-3-buten-2-one 
• 326923-93-7 (E)-4-Benzylamino-1,1,1-trifluoro-but-3-en-2-one 
• 127223-93-2 (E)-4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one 
• 503111-24-8 3-Ethoxy-5-hydroxy-5-trifluoromethylpyrrolidin-2-one 

Related news

The interaction of 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (cas 17129-06-5) with triethyl phosphite08/15/2019

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with triethyl phosphite on heating to give a [4 + 2 cycloaddition product 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene. Its hydrolysis yields, ultimately, a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ...detailed

The interaction of 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (cas 17129-06-5) with C-nucleophiles — organo-magnesium and -zinc compounds08/14/2019

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (1) reacts with phenylmagnesium bromide to give ethoxy group substitution products while the reaction of 1 with organozinc compounds gives products arising from 1,2-addition to the carbonyl group. Enone 1 reacts with electron-rich aromatic systems such as i...detailed

Study on the 1,3-dipolar cycloaddition reaction of 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (cas 17129-06-5) with nitrile oxides08/13/2019

1,3-Dipolar cycloaddition (1,3-DC) reaction of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one 1 with nitrile oxides was studied. It was found that besides its CC participating in the formation of isoxazole rings, trifluoromethyl activated CO also underwent 1,3-DC reaction with nitrile oxides to afford 1...detailed

Relevant academic research and scientific papers

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A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Continuous preparation method of trifluoromethyl butenone derivative

The invention discloses a continuous preparation method of a trifluoromethyl butenone derivative. The continuous preparation method is characterized in that a raw material 1 as shown in a structure (I) in a reaction formula and trifluoroacetyl halide serving as a raw material 2 react in a microchannel reactor to prepare the trifluoromethyl butenone derivative as shown in a structure (II). The structure (I) and the structure (II) are as described in the specification. In the structure (I) and the structure (II), R is an electron donating group and can be conjugated with olefin double bonds; R1 and R2 are independently selected from hydrogen, C1-C20 alkyl groups, aryl groups, and substituted aryl groups or silyl groups; and X is halogen and is selected from fluorine, chlorine, bromine and iodine. The method has the advantages of good process universality, good atom economy, high yield, few byproducts, high product purity and the like.

Preparation method of N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine, and the preparation method of N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine comprises the following steps: taking trifluoroacetic acid, vinyl ethyl ether, methylsulfonyl chloride and pyridine as raw materials, firstly preparing 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-ketone, carrying out ammonia ammoniation to obtain 4-amino-1, 1, 1-trifluoro-3-butene-2-ketone, then, under the action of sodium hydroxide, reacting with methyl 3-methoxyacrylate to obtain a target product N-(2-methoxycarbonyl vinyl)-4, 4, 4-trifluoro-3-ketone-1-buteneamine. The adopted raw materials are relatively cheap and easy to obtain, and the method is easy and convenient to operate, safe, feasible, high in cost performance and suitable for industrial production.

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Continuous synthesis method of 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-one

The invention provides a continuous synthesis method of 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-one. The continuous synthesis method comprises the following steps: enabling raw materials containing vinyl ethyl ether, triethylamine and trifluoroacetic anhydride to continuously enter a continuous reactor to react so as to obtain a product system containing the 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-one; performing continuous extraction on the product system to obtain the 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-one, and performing continuous extraction on the product system to obtain the 4-ethoxy-1, 1, 1-trifluoro-3-butene-2-one. By using a continuous process, the raw materials can be conveniently and accurately pumped into the continuous reactor, and after the reaction is finished, continuous extraction is also used for post-treatment, so that the whole process is quick, simple and efficient, the efficiency of the whole synthesis process is greatly improved, and the damage loss of a product is reduced; and the potential safety hazard of batch production is avoided. After amplification, an amplification effect does not exist, and safety and high synthesis efficiency can still be kept.

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Synthetic method for 6-trifluoromethyl-nicotinic acid

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