17171-08-3

Upstream product

• 67-56-1 methanol 
• 15542-37-7 (E,E)-5-(4-methoxyphenyl)-2,4-pentadienoic acid 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 292638-85-8 acrylic acid methyl ester 
• 623-43-8 crotonic acid methyl ester 
• 768-60-5 4-methoxyphenylacetylen 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 6342-88-7 (4-methoxy-cinnamylidene)-malonic acid 
• 1963-36-6 4-methoxycinnamaldehyde 
• 67629-62-3 methyl 4-(diethylphosphono)crotonate 

Downstream Products

• 443360-66-5 5t-(4-methoxy-phenyl)-penta-2t,4-dienoyl chloride 
• 66110-15-4 (2E,4E)-5-(4-methoxyphenyl)-1-(piperidine-1-yl)penta-2,4-dien-1-one 
• 15542-37-7 (E,E)-5-(4-methoxyphenyl)-2,4-pentadienoic acid 

Relevant academic research and scientific papers

TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS AND COMPOUNDS FOR SAME

The present invention relates to the treatment of disorders associated with oxidative stress including neuropathic pain and small synthetically derived compounds for treating such disorders.

(2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE

The present application relates to a novel pentadienoyl compound and a pharmaceutical composition including the same. The pentadienoyl compound of the present application may be used to prevent or treat fatty liver and fatty liver-related disease by inhibiting lipogenesis and lipid accumulation in cells and activating lipid metabolism. In addition, the pentadienoyl compound of the present application may increase a SIRT1 expression level in cells or SIRT1 activity, and thus may be used to prevent or treat a SIRT1-mediated disease. In addition, the pentadienoyl compound of the present application may reduce a CK2 expression level in cells or CK2 activity, and thus may be used to prevent or treat a CK2-mediated disease.

Microwave-accelerated Ru-catalyzed hydrovinylation of alkynes and enynes: A straightforward approach toward 1,3-dienes and 1,3,5-trienes

Quick, but not dirty! Microwave heating was found to have a significant effect on the Ru-catalyzed hydrovinylations of alkynes. A broad range of different terminal alkynes were coupled to methyl acrylate within just 30min in good to excellent yields (see scheme). This new protocol was transferred to the hydrovinylation of enynes as novel coupling partners in C-H-activation chemistry giving different 1,3,5-trienes as the sole products. Copyright

Synthetic and spectroscopic studies of structural analogs of piper amides - The 5-aryl-2E,4E-pentadienamides

The methyl esters and piperidides of fourteen 5-aryl-2E,4E-pentadienoic acids have been synthesized starting from the corresponding aryl aldehydes.

Catalytic Hunsdiecker reaction and one-pot catalytic Hunsdiecker-Heck strategy: Synthesis of α,β-unsaturated aromatic halides, α- (dihalomethyl)benzenemethanols, 5-aryl-2,4-pentadienoic acids, dienoates and dienamides

The reaction of α,β-unsaturated aromatic (or heteroaromatic) carboxylic acids with N-halosuccinimides (1 equiv.) and catalytic tetrabutylammonium trifluoroacetate (0.2 equiv.) in dichloroethane results in facile halodecarboxylation affording the corresponding (E)-halides in good to excellent yields. A similar reaction, but with 2 equiv. of N-halosuccinimides in acetonitrile-water (1:1 v/v) results in the exclusive formation of the corresponding α-(dihalomethyl)benzenemethanols. Furthermore, a one-pot strategy has been developed combining catalytic Hunsdiecker reaction (using tetrabutylammonium trifluoroacetate in dichloroethane) and Heck coupling (using palladium acetate/triethylamine/triphenylantimony/dichloroethane) for the synthesis of 5-aryl-2,4-pentadienoic acids, esters and amides in moderate to good yields. The natural product piperine and pipergualamine has been synthesized via the above route. Mechanistic and theoretical studies (via AM1 calculations) provide a useful insight into the mechanism of the present halodecarboxylation reaction, suggesting an ionic pathway involving the attack of the halogenium ion across the carbon-carbon double bond, triggering the elimination of carbon dioxide. (C) 2000 Elsevier Science Ltd.

Substituent Effects on Carbon-13 NMR Chemical Shifts of Side-chain Carbons in 5-Aryl-2E,4E-pentadienoic Acid Derivatives

The 13C NMR spectra of two series of 5-aryl-2E,4E-pentadienoic acid derivatives, viz. the methyl esters and piperidides have been determined.The chemical shifts of C-2 and C-4 show very good correlations with the Hammett ?+-constants for all the substituents investigated, except for the para-nitro group which is capable of excerting a strong -R effect.A possible explanation for this has been advanced.Hammett correlations between substituents and the chemical shifts of both C-3 and C-5 carbons using ?0 parameters are less satisfactory.A reverse chemical shift effect has been observed for these two centres.