172275-56-8Relevant academic research and scientific papers
A focus on the asymmetric synthesis of a novel threo-β-benzyl-β- hydroxy aspartate analogue
Mekki, Sofiane,Bellahouel, Salima,Vanthuyne, Nicolas,Rolland, Marc,Derdour, Aicha,Martinez, Jean,Vignes, Michel,Rolland, Valerie
experimental part, p. 94 - 99 (2012/05/20)
Considering the biological activity of β-alkyl-β-hydroxyaspartate derivatives as potent blockers of glutamate transporters (EAATs) impacting on glutamatergic synapses activity, we have developed a concise, asymmetric synthesis of enantiomerically pure thr
Stereospecific high-affinity TRPV1 antagonists: Chiral N-(2-benzyl-3- pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues
Ryu, Hyungchul,Jin, Mi-Kyoung,Su, Yeon Kim,Choi, Hyun-Kyung,Kang, Sang-Uk,Dong, Wook Kang,Lee, Jeewoo,Pearce, Larry V.,Pavlyukovets, Vladimir A.,Morgan, Matthew A.,Tran, Richard,Toth, Attila,Lundberg, Daniel J.,Blumberg, Peter M.
, p. 57 - 67 (2008/09/18)
Previously, we reported the thiourea antagonists 2a and 2b as potent and high affinity TRPV1 antagonists. For further optimization of the lead compounds, a series of their amide and α-substituted amide surrogates were investigated and novel chiral N-(2-be
