172420-63-2

Basic information

• Product Name: 2-Butanone, 3-(diphenylphosphinyl)-4-phenyl-
• CAS NO: 172420-63-2
• Molecular Formula: C22H21O2P
• Molecular Weight: 348.381
• Mol File: 172420-63-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 3-(diphenylphosphinyl)-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 3-(diphenylphosphinyl)-4-phenyl-(172420-63-2)
• EPA Substance Registry System: 2-Butanone, 3-(diphenylphosphinyl)-4-phenyl-(172420-63-2)

Safety Data

• Hazardous Substances Data: 172420-63-2(Hazardous Substances Data)

Upstream product

• 2129-89-7 diphenyl(methyl)phosphine oxide 
• 3582-84-1 (2-phenylethyl)diphenylphosphine oxide 
• 141-78-6 ethyl acetate 
• 1733-52-4 1-(diphenylphosphinoyl)propan-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 2550-26-7 4-Phenyl-2-butanone 
• 115693-91-9 (2R,3R)-2-(Diphenyl-phosphinoyl)-3-methyl-1-phenyl-pentan-3-ol 
• 115693-91-9 (2R,3S)-2-(Diphenyl-phosphinoyl)-3-methyl-1-phenyl-pentan-3-ol 

Relevant articles and documents

Diphenylphosphinoyl-mediated synthesis of ketones

α-Diphenylphosphinoyl ketones are selectively and sequentially alkylated at the α-position. Double lithiation and selective alkylation occurs at the less stabilised γ-position. Dephosphinoylation of the alkylation products gives ketones. Mono-alkylation is selective, highly crystalline intermediates are formed and a one-pot strategy is possible. The method is ideally suited for the preparation of acid-sensitive ketones. The Royal Society of Chemistry 2006.

TiCl4 mediated LiBH4 reduction of β-ketophosphine oxides: A high stereoselective route to the synthesis of anti-β-hydroxyphosphine oxides

The reduction of an α-alkyl-β-ketophosphine oxide with LiBH4 in presence of a strong chelating agent, such as TiCl4, gives the corresponding β-hydroxyphosphine oxide in high yields and with high anti-diastereoselectivity independently from the size of both the α- and β-alkyl chains.