172720-97-7

Basic information

• Product Name: Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl
• Synonyms: Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl
• CAS NO: 172720-97-7
• Molecular Formula: C11H19NO3
• Molecular Weight: 213.27346
• Product Categories: N-BOC
• Mol File: 172720-97-7.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl(172720-97-7)
• EPA Substance Registry System: Carbamic acid, [4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl(172720-97-7)

Safety Data

• Hazardous Substances Data: 172720-97-7(Hazardous Substances Data)

Usage

Uses

rel-N-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of the HIV reverse transcriptase inhibitor ziagen.

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 130931-83-8 (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one 
• 151907-80-1 (1R,4S)-4-[(tert-butoxycarbonyl)amino]cyclopent-2-ene-1-carboxylic acid 
• 4157-02-2 cis 2-cyclopentene 1,4-dibenzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 136522-35-5 (1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene 
• 168683-02-1 (1S,4R)-(-)-methyl-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopent-2-ene-1-carboxylate 
• 168960-19-8 (1R,4S)-1-amino-4-(hydroxymethyl)-2-cyclopentene hydrochloride 
• 151792-53-9 tert-butyl (1R,4S)-(-)-3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 157555-70-9 Benzoic acid (1S,4R)-4-amino-cyclopent-2-enyl ester 
• 33797-51-2 eschenmoser's salt 
• 189625-14-7 (2S,4R)-acetic acid 4-tert-butoxycarbonylaminocyclopent-2-enyl ester 
• 7285-11-2 chloroform methanol 

Downstream Products

• 136522-35-5 (1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene 
• 121481-90-1 (+/-)-cis-(4-hydroxymethyl)cyclopent-2-en-1-ylamine 
• 168960-19-8 (1S,4R)-1-amino-4-hydroxymethyl-2-cyclopentene hydrochloride 
• 1233843-46-3 C₆H₁₁NO*ClH 
• 77745-28-9 cis-4-Aminocyclopent-2-enemethanol Hydrochloride 
• 141271-12-7 (1S, 4R)-(4-(2,5-diamino-6-chloro-4-pyrimidinyl)amino)-2-cyclopenten-1-methanol 
• 220285-03-0 [(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methanol 
• 158799-91-8 (1R,cis)-4-(6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol 
• 168960-19-8 (1R,4S)-1-amino-4-(hydroxymethyl)-2-cyclopentene hydrochloride 
• 112966-73-1 [(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methanol 
• 918492-98-5 (1α,4α)-4-(6-Chloro-9H-purin-9-yl)-2-cyclopentenyl-carbinol 

Relevant articles and documents

The Synthesis of trans-Carbovir via the Ramberg-Baecklund Reaction

A novel Ramberg-Baecklund approach to the synthesis of 1-amino-4-substituted cyclopentenes is described and applied to prepare the trans-isomer of the carbocyclic nucleoside carbovir.

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors

Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was used to inform key structural changes. Through key substitutions about the N1 and C5 N positions on the pyrazole ring significant kinase selectivity and potency were achieved. Bridged bicyclic pyrazolocarboxamide 11 represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.

Optical pure amino alcohol hydrochloride preparation method

The invention relates to a preparation method for optically pure aminoalcohol hydrochloride. The optically pure aminoalcohol hydrochloride is any one selected from optically pure aminoalcohol hydrochloride 1 and optically pure aminoalcohol hydrochloride 2 and is prepared by subjecting a compound 4 to an esterification ring-opening reaction, an amino protection reaction, an ester reduction reaction and a deprotection salt forming reaction. The optically pure aminoalcohol hydrochloride 1 or optically pure aminoalcohol hydrochloride 2 prepared in the invention can be directly used for synthesis of abacavir and carbovir. The preparation method provided by the invention has the advantages of high product optical purity, stable product quality, high product yield, a small amount of environmental pollution, low production cost, easy industrialization, etc.