1845-11-0

Basic information

• Product Name: Nafoxidine
• Synonyms: 1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenylnaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;1-[2-[p-(3,4-Dihydro-6-methoxy-2-phenylnaphthalen-1-yl)phenoxy]ethyl]pyrrolidine;1-(2-(4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)pyrrolidene;Nafoxidine;1-{2-[4-(6-Methoxy-2-phenyl-3,4-dihydro-1-naphthalenyl)phenoxy]ethyl}pyrrolidine
• CAS NO: 1845-11-0
• Molecular Formula: C₂₉H₃₁NO₂
• Molecular Weight: 425.56
• Mol File: 1845-11-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 541.28°C (rough estimate)
• Flash Point: 176.7°C
• Appearance: /
• Density: 1.0990 (rough estimate)
• Refractive Index: 1.6290 (estimate)
• CAS DataBase Reference: Nafoxidine(CAS DataBase Reference)
• NIST Chemistry Reference: Nafoxidine(1845-11-0)
• EPA Substance Registry System: Nafoxidine(1845-11-0)

Safety Data

• Hazardous Substances Data: 1845-11-0(Hazardous Substances Data)

Usage

Uses

Anti-estrogen.

InChI:InChI=1/C29H31NO2/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3

Upstream product

• 1729-38-0 1-(p-hydroxyphenyl)-6-methoxy-2-phenyl-3,4-dihydronaphthalene 
• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 
• 5050-41-9 N-(2-chloroethyl)-pyrrolidine 
• 123-75-1 pyrrolidine 
• 1449689-98-8 4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene 
• 17878-44-3 (4-bromophenoxy)trimethylsilane 
• 1769-84-2 6-methoxy-2-phenyl-1-tetralone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 1081-73-8 1-[2-(4-bromophenoxy)ethyl]pyrrolidine 
• 180915-95-1 1-{2-[4-(2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1847-63-8 1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride 
• 180915-78-0 (5S,6S)-6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalen-2-ol 
• 180916-16-9 lasofoxifene 
• 180915-78-0 (5S,6R)-6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalen-2-ol 
• 180915-78-0 lasofoxifene 

Relevant articles and documents

Copper-catalyzed carboarylation of alkynes via vinyl cations

Copper-catalyzed arylation of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalents that react with pendant arene nucleophiles to form all carbon tetrasubstituted alkenes. The new process streamlines the synthesis of important medicinally relevant molecules.

Process for the preparation of alfa-substituted ketones and their application in synthesis of pharmaceutically active compounds

The present invention relates to a novel one step preparation of 6-methoxy-2-phenyl-tetralone starting from 6-methoxy-tetralone and its use as an intermediate in the synthesis of pharmaceutically active compounds.

A PROCESS FOR THE PREPARATION OF LASOFOXIFENE TARTRATE

The present invention relates to solid state chemistry of 1-(2-[4-(6-methoxy-3,4-dihydronaphthalene-1-yl) phenoxy]ethyl)pyrrolidine, a process for its preparation and its use as an intermediate in the synthesis of lasofoxifene.