173035-10-4Relevant articles and documents
Highly efficient palladacycle/dihydroimidazolium chloride system for the suzuki-miyaura cross-coupling of aryl halides (I, Br, Cl) with arylboronic acids
Wang, Haiming,Wang, Jinping,Qiu, Wenwei,Yang, Fan,Liu, Xiaofeng,Tang, Jie
, p. 2416 - 2420 (2010)
A combination of a tertiary amine-based palladacycle and an N-heterocyclic carbene ligand precursor (1, N,N-bis-mesityl-4,5-dihydroimidazolium chloride) has been applied to catalyze the Suzuki-Miyaura cross-coupling of aryl halides with arylboronic acids. The substrate scope is general: a variety of electron rich and deficient aryl halides (I, Br, Cl) and arylboronic acids were found to undergo the cross-coupling reaction in good to excellent yields at low catalyst loading of 0.01-1 mol%. A combination of a tertiary amine-based palladacycle and an N-heterocyclic carbene ligand precursor has been applied to catalyze the Suzuki-Miyaura cross-coupling of aryl halides with arylboronic acids. Varieties of electron rich and deficient aryl halides (I, Br, Cl) and arylboronic acids were found to undergo the cross-coupling reaction in good to excellent yields at low catalyst loading of 0.01-1 mol%.
Application of Quantitative 1H and 19F NMR to Organometallics
Akhdar, Ayman,Andanson, Jean-Michel,Faure, Sophie,Gautier, Arnaud,Tra?kia, Mounir
, (2021/08/03)
Purity assessment of organometallics is particularly important for catalytic applications. While quantitative NMR is a well-known method in pharmaceutic chemistry, the present work illustrates its usefulness for the determination of the ligands and organometallics purities using proton and fluorine NMR. This method is fast, straightforward and provides accuracy results.
Hoveyda–Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors
Polyanskii, Kirill B.,Alekseeva, Kseniia A.,Raspertov, Pavel V.,Kumandin, Pavel A.,Nikitina, Eugeniya V.,Gurbanov, Atash V.,Zubkov, Fedor I.
supporting information, p. 769 - 779 (2019/04/17)
A novel and efficient approach to the synthesis of 2-vinylbenzylamines is reported. This involves obtaining 2-vinylbenzylamine ligands from tetrahydroisoquinoline by alkylation and reduction followed by the Hofmann cleavage. The resultant 2-vinylbenzyl-amines allowed us to obtain new Hoveyda–Grubbs catalysts, which were thoroughly characterised by NMR, ESIMS, and X-ray crystallography. The utility of this chemistry is further demonstrated by the tests of the novel catalysts (up to 10?2 mol %) in different metathesis reactions such as cross metathesis (CM), ring-closing metathesis (RCM) and ring-opening cross metathesis (ROCM).
Improved microwave synthesis of unsymmetrical N,N'-diaryl-1,2-aminoethane and imidazolidinium salts as precursors of N-heterocyclic carbenes
Ibrahim, Yehia A.,Al-Awadi, Nouria A.,Al-Azemi, Talal F.,John, Elizabeth
, p. 38869 - 38876 (2014/11/08)
Lithium aluminium hydride reduction of bis-unsymmetric-diaryloxamides 3 is difficult to accomplish especially for the sterically hindered mesityl derivative. Using microwaves LAH reduction of 3a,d was successful in a short time, however, with cleavage of the ether linkage to give compounds 11a,d. Extension of this method enabled the reduction of bis-oxamide derivatives 13 to the corresponding tetraamine derivative 14 which was then converted to the bis-imidazolidinium salt 15. Application of this method led to rapid reduction of unsymmetric N,N'-diaryloxamides 16 to the corresponding N,N'- diarylethylenediamines 17 which were converted to their corresponding imidazolidinium salts 18. the Partner Organisations 2014.
