173974-88-4

Usage

Uses

Used in Pharmaceutical Research:
1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE is used as a building block in pharmaceutical research for its potential to contribute to the development of new drugs. Its unique structure allows for various chemical reactions and modifications, which can lead to the creation of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE is used as a key intermediate for the synthesis of various complex organic compounds. Its reactivity and structural features make it a versatile component in the construction of a wide range of molecules.
Used in Agricultural and Chemical Industries:
1-(4-BROMOPHENYL)-2,2-DIFLUOROETHANONE may also find applications in the agricultural and chemical industries as a precursor to other compounds. Its unique properties can be harnessed to produce a variety of products, contributing to the advancement of these industries.

Upstream product

• 173974-85-1 N-(1-4'-bromophenylethylidene)-n-butylamine 
• 413598-07-9 ((1-(4-bromophenyl)-2,2-difluorovinyl)oxy)trimethylsilane 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 67-56-1 methanol 
• 99-90-1 para-bromoacetophenone 
• 1337572-02-7 C₁₇H₁₉BrF₂O₂SSi 
• 586-75-4 4-chlorobenzoyl chloride 
• 18931-61-8 4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione 
• 454-31-9 ethyl difluoroacetate 
• 589-87-7 1,4-bromoiodobenzene 
• 586-76-5 4-Bromobenzoic acid 
• 64929-35-7 3-(4-bromophenyl)-3-oxopropanoic acid 
• 106-37-6 1.4-dibromobenzene 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 887781-91-1 1-bromo-4-(3,3-difluoroprop-1-en-2-yl)benzene 
• 887781-90-0 2-(4-bromophenyl)-1,1-difluoropropan-2-ol 
• 1022154-90-0 2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone 
• 1217864-27-1 C₈H₆⁽²⁾HBrF₂O 
• 887781-84-2 (1R)-1-(4-bromophenyl)-2,2-difluoroethanol 
• 887781-85-3 (S)-1-(4-bromophenyl)-2,2-difluoroethanol 

Relevant academic research and scientific papers

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Transaminases as suitable catalysts for the synthesis of enantiopure β,β-difluoroamines

Transaminases have shown the ability to catalyze the amination of a series of aliphatic and (hetero)aromatic α,α-difluorinated ketones with high stereoselectivity, thus providing the corresponding β,β-difluoroamines in high isolated yields (55–82%) and ex

Direct electrochemical hydrodefluorination of trifluoromethylketones enabled by non-protic conditions

CF2H groups are unique due to the combination of their lipophilic and hydrogen bonding properties. The strength of H-bonding is determined by the group to which it is appended. Several functional groups have been explored in this context includ

Direct Synthesis of Tri-/Difluoromethyl Ketones from Carboxylic Acids by Cross-Coupling with Acyloxyphosphonium Ions

A simple and straightforward approach to the synthesis of trifluoromethyl and difluoromethyl ketones from widely available carboxylic acids is disclosed. The transformation utilizes an acyloxyphosphonium ion as the active electrophile, conveniently generated in situ from the carboxylic acid substrate by using commodity chemicals. The utility of the reaction system is exemplified by its chemoselectivity, with tolerance to a variety of important functional groups. The late-stage functionalization of carboxylic acid active pharmaceutical ingredients and pharmaceutically relevant compounds is also discussed.

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

CATHEPSIN K INHIBITOR AND APPLICATION THEREOF

The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.

Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres

A geminal difluorination of alkenes based on I(I)/I(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally diverse styrenes (27 examples, up to 89% yield). Employing inexpensive p-TolI as the organocatalyst, turnover is enabled by Selectfluor-mediated oxidation to generate the ArIF2 species in situ. Extension to include α-substituted styrenes bearing fluorine-containing groups is disclosed and provides an expansive platform for the generation of fluorine-rich architectures.