1045709-32-7

Basic information

• Product Name: 2-Oxa-6-azaspiro[3.3]heptane hemioxalate
• Synonyms: 2-Oxa-6-aza-spiro[3,3]heptane-6-carboxylic acid tert-butyl ester;2-Oxa-6-aza-spiro[3.3]hep...;2-Oxa-6-azaspiro[3.3]heptane hemioxalate;2-Oxa-6-azaspiro[3.3]heptane, ethanedioate (2:1);2-Oxa-6-azaspiro[3.3]heptane oxalate (2:1);tert-butyl 2-oxa-6-azaspiro[3.3]heptane-6-carboxylate;2-Oxa-6-azaspiro[3.3]heptane oxalic acid salt (2:1);2-Oxa-6-azaspiro[3.3]heptane 1/2 oxalate
• CAS NO: 1045709-32-7
• Molecular Formula: 2(C5H9NO).C2H2O4
• Molecular Weight: 288.3
• Product Categories: Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Oxetanes
• Mol File: 1045709-32-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Oxa-6-azaspiro[3.3]heptane hemioxalate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxa-6-azaspiro[3.3]heptane hemioxalate(1045709-32-7)
• EPA Substance Registry System: 2-Oxa-6-azaspiro[3.3]heptane hemioxalate(1045709-32-7)

Safety Data

• Hazardous Substances Data: 1045709-32-7(Hazardous Substances Data)

Usage

General Description

2-Oxa-6-azaspiro[3.3]heptane hemioxalate is a chemical compound with the molecular formula C6H8N2O4. It is a hemioxalate salt of the organic compound 2-oxa-6-azaspiro[3.3]heptane, which is a heterocyclic compound containing a spiro ring. The chemical structure of 2-oxa-6-azaspiro[3.3]heptane hemioxalate consists of a spiro ring system with a nitrogen and oxygen atom incorporated within the ring. 2-Oxa-6-azaspiro[3.3]heptane hemioxalate may have applications in pharmaceuticals, agrochemicals, and material science, and its properties and potential uses warrant further investigation.

Upstream product

• 2402-83-7 3,3-bis(bromomethyl)oxetane 
• 78-71-7 3,3-bis(chloromethyl)oxetane 
• 1522-92-5 2,2-bis(bromomethyl)-3-bromo-propan-1-ol 
• 144-62-7 oxalic acid 
• 46246-91-7 2-benzyl-6-oxa-2-azaspiro[3.3]-heptane 
• 13573-28-9 6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane 
• 174-78-7 2-oxa-6-azaspiro[3.3]heptane 

Downstream Products

• 1449279-91-7 N-((1S,2R)-2-hydroxy-3-oxo-1-phenyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)propyl)-benzamide 
• 1449279-92-8 tert-butyl (1S,2R)-2-hydroxy-3-oxo-1-phenyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-propylcarbamate 
• 1449279-89-3 (4S,5R)-(3-benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidin-5-yl)(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone 
• 1449279-90-6 (4S,5R)-tert-butyl-2-(4-methoxyphenyl)-4-phenyl-5-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)oxazolidine-3-carboxylate 
• 1426257-54-6 2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethan-1-one 
• 1549705-95-4 4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one 
• 1549706-61-7 ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate 
• 1431648-15-5 N-(6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridin-2-yl)-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxamide 
• 1449710-19-3 5-{2-[3-methoxy-4-(2-oxa-6-azaspiro[3.3]heptane-6-carbonyl)phenyl]furo[3,2-b]pyridin-7-yl}-2-(tetrahydropyran-4-yloxy)benzonitrile 
• 1370444-27-1 2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide 
• 1227159-75-2 6-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridin-2-yl}-2-oxa-6-azaspiro[3.3]heptane 
• 1254035-85-2 (3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenylthio)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone 
• 1254035-94-3 4-(2-oxa-6-azaspiro[3.3]hept-6-ylmethyl)phenol 
• 1240402-44-1 {3-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-isoxazol-5-yl}-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-methanone 

Relevant articles and documents

Spirocyclic oxetanes: Synthesis and properties

(Chemical Presented) Wormholes through chemical space: Spirocyclic oxetanes are described as analogues of morpholine and also as topological siblings of their carbonyl counterparts. They are particularly promising in terms of both their physicochemical properties and the ease with which they can be grafted onto molecular structures. The data collected highlight oxetanes as both the hydrophilic sister of a gem-dimethyl unit and the carbonyl group's lipophilic brother.

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

An improved synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. While this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these improved properties access to a wider range of reaction conditions with the spirobicyclic 2-oxa-6-azaspiro[3.3]heptane has been enabled.

SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY

The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.