17408-15-0

Usage

Uses

Used in Pharmaceutical Industry:
2-nitropropiophenone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be chemically modified and incorporated into drug molecules, contributing to the development of new medications.
Used in Dye and Pigment Industry:
2-nitropropiophenone is used as a precursor in the production of dyes and organic pigments, where its chemical structure can be utilized to create a wide range of colorants for different applications.
Used in Organic Synthesis:
2-nitropropiophenone is used as a versatile building block in organic synthesis, allowing for the creation of a variety of organic molecules for research and industrial purposes.
Used in Chemical Research:
2-nitropropiophenone serves as a subject of study in chemical research, where its properties and reactions are explored to further understand and develop new chemical processes and compounds.

InChI:InChI=1/C9H9NO3/c1-2-9(11)7-5-3-4-6-8(7)10(12)13/h3-6H,2H2,1H3

Upstream product

• 7137-54-4 1-nitro-2-propyl-benzene 
• 93-55-0 1-phenyl-propan-1-one 
• 34812-95-8 1,3-di-tert-butyl 2-methylpropanedioate 
• 610-14-0 2-nitrobenzyl chloride 
• 7664-93-9 sulfuric acid 
• 323579-94-8 1-(2-nitrophenyl)-2-propen-1-ol 
• 75039-34-8 (E)-propiophenone O-methyl oxime 
• 1439930-82-1 (E)-1-(2-nitrophenyl)propionyl O-methyl oxime 
• 609-73-4 o-nitroiodobenzene 
• 79-03-8 propionyl chloride 
• 10292-65-6 2-nitrophenylcyclopropane 
• 90972-31-9 2-(1-Hydroxypropyl)nitrobenzene 
• 93-54-9 1-Phenyl-1-propanol 

Downstream Products

• 10352-60-0 2,3-dimethylquinolin-4-ol 
• 6943-08-4 4-hydroxy-3-methyl-2-phenylquinoline 
• 52457-99-5 1-(2-acetylaminophenyl)-1-propanone 
• 13837-11-1 N-(2-propionylphenyl)propionamide 
• 351342-74-0 N-(2-propionylphenyl)benzamide 
• 861598-90-5 butyric acid-(2-propionyl-anilide) 
• 6269-45-0 2-(2-nitrophenyl)benzo[d]thiazole 
• 98-95-3 nitrobenzene 
• 90972-31-9 2-(1-Hydroxypropyl)nitrobenzene 
• 37465-77-3 3-(2-Nitro-phenyl)-pent-1-yn-3-ol 
• 1196-28-7 2'-Aminopropiophenon 

Relevant academic research and scientific papers

Synthesis of Indolines and Derivatives by Aza-Heck Cyclization

For the first time, an aza-Heck cyclization that allows the preparation of indoline scaffolds is described. Using N-hydroxy anilines as electrophiles, which can be easily accessed from the corresponding nitroarenes, this method provides indolines bearing pendant functionality and complex ring topologies. Synthesis of challenging indolines, such as those bearing fully substituted carbon atoms at C2, is also possible using this method.

Palladium-catalyzed chelation-assisted aromatic C-H nitration: Regiospecific synthesis of nitroarenes free from the effect of the orientation rules

A palladium-catalyzed chelation-assisted ortho-nitration of aryl C-H bond is described. A range of azaarenes such as 2-arylquinoxalines, pyridines, quinoline, and pyrazoles were nitrated with excellent chemo- and regioselectivity. Using the O-methyl oximyl group as a removable directing group, the regiospecific synthesis of a variety of o-nitro aryl ketones was achieved starting from aryl ketones via a three-step process involving the Pd-catalyzed ipso-nitration of C-H bond as a key step. Mechanistic investigations support a silver-mediated radical mechanism involving Pd((II/III) and/or Pd(II/IV) catalytic cycles under oxidizing conditions.

Pentamethylcyclopentadienyl ruthenium: an efficient catalyst for the redox isomerization of functionalized allylic alcohols into carbonyl compounds

The catalytic activity of the ruthenium(II) complex [RuCp*(CH3CN)3][PF6] 1 in the transposition of allylic alcohols into carbonyl compounds, in acetonitrile, is reported. This catalyst has proven to be able to catalyze the transformation of poorly reactive and/or functionalized substrates under smooth conditions.

Ozone-mediated Nitration of Aromatic Ketones and Related Compounds with Nitrogen Dioxide

Alkyl aryl ketones react smoothly with nitrogen dioxide at low temperatures in the presence of ozone to give ortho- and meta-nitro derivatives as the principal products, the former usually being predominant (ortho:meta = 1.1-3.8:1.0).No attack was observed on the alkyl side chains.

CONVERSION OF 2,1-BENZISOXAZOLINIUM IONS TO ANTHRANILS BY TREATMENT WITH HYDROHALIC ACIDS

2,1-Benzisoxazolinium ions, obtained from o-nitrophenylcyclopropanes, react with hydrobromic and hydrochloric acids to give halo-substituted benzoisoxazoles.