1743-31-3

Basic information

• Product Name: 1-Hexen-5-yn-3-ol, 1-phenyl-, (1E)-
• CAS NO: 1743-31-3
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Mol File: 1743-31-3.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: 1-Hexen-5-yn-3-ol, 1-phenyl-, (1E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hexen-5-yn-3-ol, 1-phenyl-, (1E)-(1743-31-3)
• EPA Substance Registry System: 1-Hexen-5-yn-3-ol, 1-phenyl-, (1E)-(1743-31-3)

Safety Data

• Hazardous Substances Data: 1743-31-3(Hazardous Substances Data)

Usage

Class

Alkynols

Contains

Both an alkene and an alkyne group

Type of compound

Unsaturated alcohol

Substituent

Phenyl group attached to the first carbon of the alkene group

Usage

Building block in organic synthesis, particularly in the preparation of pharmaceuticals and other fine chemicals

Studied for

Potential biological and pharmacological activities, including antimicrobial, antioxidant, and anti-inflammatory properties.

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 865350-17-0 4,4,5,5-tetramethyl-2-(propa-1,2-dien-1-yl)-1,3,2-dioxaborolane 
• 33415-30-4 trichloro(propa-1,2-dienyl)silane 
• 75-16-1 methylmagnesium bromide 
• 4364-06-1 (E)-cinnamaldehyde dimethylacetal 
• 106-96-7 propargyl bromide 
• 110966-13-7 (E)-(3-(prop-2-yn-1-yloxy)prop-1-en-1-yl)benzene 
• 104-55-2 3-phenyl-propenal 

Downstream Products

• 57872-17-0 (E)-7-phenyl-6-ene-5-hydroxy-2-heptinoic acid 
• 1321942-08-8 (E)-1-phenylhexa-1,4,5-trien-3-one 
• 1321942-27-1 (E)-4-oxo-6-phenylhexa-1,5-dien-2-yl 2,2,2-trifluoroacetate 
• 1321942-30-6 (E)-1-(3,4-dimethyl-6-methylenecyclohex-3-enyl)-3-phenylprop-2-en-1-one 
• 117930-27-5 (3Z,5E)-4-hydroxy-6-phenylhexa-3,5-dien-2-one 
• 105122-39-2 4-Methylen-3-phenyl-2-cyclopenten-1-on 
• 1393749-89-7 (E)-4-hydroxy-1,6-diphenylhex-5-en-1-one 

Relevant articles and documents

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One-pot, regioselective synthesis of homopropargyl alcohols using pro-pargyl bromide and carbonyl compound by the mg-mediated reaction under solvent-free conditions

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

Efficient method for propargylation of aldehydes promoted by allenylboron compounds under microwave irradiation

The propargylation of aldehydes promoted by microwave irradiation using allenylboron compounds in a chemo- and regioselective way is described. The corresponding products were obtained in short reaction time, high yield and purity without the need of any solvent when allenylboronic acid pinacol ester was used, or using a minimal amount of acetone when potassium allenyltrifluoroborate was used.