1743-54-0

Basic information

• Product Name: (±)-2,3-bis(4-chlorophenyl)propanoic acid
• Synonyms: (±)-2,3-bis(4-chlorophenyl)propanoic acid
• CAS NO: 1743-54-0
• Molecular Weight: 295.165
• Mol File: 1743-54-0.mol

Chemical Properties

• CAS DataBase Reference: (±)-2,3-bis(4-chlorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-2,3-bis(4-chlorophenyl)propanoic acid(1743-54-0)
• EPA Substance Registry System: (±)-2,3-bis(4-chlorophenyl)propanoic acid(1743-54-0)

Safety Data

• Hazardous Substances Data: 1743-54-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(±)-2,3-bis(4-chlorophenyl)propanoic acid is used as an anti-inflammatory and analgesic agent for the treatment of pain, inflammation, and stiffness caused by arthritis, gout, and other musculoskeletal conditions. It is effective in reducing inflammation and pain by inhibiting the production of certain chemicals in the body.
Used in Healthcare:
(±)-2,3-bis(4-chlorophenyl)propanoic acid is used as a medication to alleviate the symptoms of arthritis, gout, and other musculoskeletal conditions. It is typically taken in oral tablet form and is prescribed by healthcare professionals to be taken multiple times daily as directed.
It is important to use fenoprofen as prescribed and to be aware of potential side effects, which may include stomach upset, heartburn, and dizziness.

Upstream product

• 124-38-9 carbon dioxide 
• 5121-74-4 4,4'-dichlorostylbene 
• 36770-81-7 2,3-bis(4-chlorophenyl)propanenitrile 
• 1657-63-2 (E)-2,3-bis(4-chlorophenyl)-2-propenoic acid 

Downstream Products

• 23909-35-5 2-(p-Chlor-phenyl)-6-chlor-indanon-⁽¹⁾ 

Relevant articles and documents

Caesium fluoride-mediated hydrocarboxylation of alkenes and allenes: Scope and mechanistic insights

A caesium fluoride-mediated hydrocarboxylation of olefins is disclosed that does not rely on precious transition metal catalysts and ligands. The reaction occurs at atmospheric pressures of CO2 in the presence of 9-BBN as a stoichiometric reductant. Stilbenes, β-substituted styrenes and allenes could be carboxylated in good yields. The developed methodology can be used for preparation of commercial drugs as well as for gram scale hydrocarboxylation. Computational studies indicate that the reaction occurs via formation of an organocaesium intermediate.

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

Reactions of chlorine substituted (E)-2,3-diphenylpropenoic acids over cinchonidine-modified Pd: Enantioselective hydrogenation versus hydrodechlorination

The effect of the chlorine position on the C-Cl bond hydrogenolysis and the enantioselective hydrogenation of Cl substituted (E)-2,3-diphenylpropenoic acid derivatives has been studied over cinchonidine-modified Pd/Al2O 3. In contrast to the fast hydrodechlorination of the β-phenyl-para-Cl substituted acids the Cl on the α-phenyl ring was barely hydrogenolized. These observations were interpreted by the different arrangements of the two phenyl rings on the surface, with the α- and β-phenyl rings adsorbed tilted and parallel, respectively. The results confirmed the beneficial effect of the α-phenyl-ortho-substituents on the chiral discrimination, thus the 2,3-diphenylpropionic acids substituted by Cl on the α-phenyl ring could be prepared in good yields and optical purities. The conclusions were used for the rational design of an acid, i.e. (E)-2-(2-methoxyphenyl)-3-(3,4-difluorophenyl)propenoic acid, which afforded the best optical purity (ee up to 95% at 295 K) described until now in this heterogeneous system.