59563-84-7

Upstream product

• 89549-77-9 Benzoic acid cyano-phenyl-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methyl ester 
• 5334-48-5 4-chloro-1-(phenyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 100-52-7 benzaldehyde 
• 1681-56-7 1,3-dimethyl-2-(α-hydroxybenzyl)benzimidazolium iodide 
• 66421-39-4 1-phenyl-4-(toluene-4-sulfonyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 4242-46-0 1-cyanobenzyl benzoate 
• 17452-05-0 (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol 
• 30517-60-3 (1-methyl-1H-imidazol-2-yl)-phenylmethanol 
• 205640-06-8 4-iodo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine 

Downstream Products

• 89549-57-5 4-phenyl-4,5-dihydro-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carboxylic acid 
• 53645-78-6 1-phenyl-4-phenylpyrazolo<3,4-d>pyrimidine 
• 76990-17-5 6-anilino-4-phenyl-5-pyrimidinecarbonitrile 

Relevant academic research and scientific papers

Several approaches to cyanide ion-catalyzed synthesis of 4-aroyl-1-phenyl-1h-pyrazolo[3,4-d]pyrimidines

- 4-Aroyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidines (5) were formed in low yields by reaction of 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (4) with arenecarbaldehydes (3) in the presence of potassium cyanide. Similar reaction of 4-tosyl-1-phenyl-1H-pyra

Synthesis and reactivities of 1,3-dimethyl-2-(α-hydroxy-benzyl)imidazolium and 1,3-dimethyl-2-(α-hydroxybenzyl)benzimidazolium iodides

1,3-Dimethyl-2-(α-hydroxybenzyl)benzimidazolium iodide (3a) was synthesized from 1-methylbenzimidazole (10) through two steps involving lithiation and quaternization. Treatment of 3a with 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (6) afforded 4-benzoyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (15a). 4-Benzoylquinazoline (14a) and 7-benzoyl-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidine (16a) were given by reaction of 3a with 4-chloroquinazoline (5) and 7-chloro-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidine (7). Treatment of 3a with benzaldehyde (9a) gave benzoin (8a). Similar results were obtained in the reactions of 1,3-dimethyl-2-(α-hydroxybenzyl)imidazolium iodide (4a).

Azolium salts as effective catalysts for benzoin condensation and related reactions

A catalytic ability of several azolium salts for benzoin condensation, the benzoylation of 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine, and oxidative aroylation was examined. We found that azolium salts having an imidazolium moiety, such as 1,4-dimethy

Studies on Pyrazolopyrimidine Derivatives. XIII. Aryl Migration of 4-Aroyl-1H-pyrazolopyrimidines to 4-Aryl-4,5-dihydro-1H-pyrazolopyrimidine-4-carboxylic Acids

When a mixture of 4-aroyl-1-phenyl-1H-pyrazolopyrimidines (3) and sodium hydroxide in dimethyl sulfoxide (DMSO) was stirred for 1 h at room temperature, migration of the aryl group to the 4-position occurred, i.e., the benzilic acid rearrangement,