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Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A- 85380)

DOI: 10.1002/(SICI)1099-1344(199804)41:4<309::AID-JLCR78>3.0.CO;2-I

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 309 - 318 (1998)

Update date:2022-08-30

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Authors:

Horti, Andrew G.Horti, Andrew G.

Koren, Andrei O.Koren, Andrei O.

Ravert, Hayden T.Ravert, Hayden T.

Musachio, John L.Musachio, John L.

Mathews, William B.Mathews, William B.

London, Edythe D.London, Edythe D.

Dannals, Robert F.Dannals, Robert F.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199804)41:4<309::AID-JLCR78>3.0.CO;2-I

The radiochemical synthesis of 2-[18F]fluoro-3-(2(S)- azetidinylmethoxy)pyridine (2-[18F]A-85380, [18F]1) was accomplished by Kryptofix 222 assisted nucleophilic no-carrier-added [18F]fluorination of 2-iodo-3-((1-tert-butoxycarbonyl-2(S)-azetidinyl)methoxy)pyridine, 2 followed by acidic deprotection. The average radiochemical yield was 10% and the average specific radioactivity was 1050 mCi/μmol, calculated at end-of- synthesis (EOS).

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Full text of DOI:10.1002/(SICI)1099-1344(199804)41:4<309::AID-JLCR78>3.0.CO;2-I

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Product name:2-Fluoro-3-hydroxypyridine

Cas No:174669-74-0

174669-74-0

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