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174734-34-0

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174734-34-0 Usage

General Description

5-Methoxy-2-trifluoromethylindole is a chemical compound with the molecular formula C10H8F3NO. It is a derivative of indole, a heterocyclic aromatic organic compound. The trifluoromethyl group and the methoxy group attached to the indole ring make this compound a valuable building block for the synthesis of various pharmaceuticals and agrochemicals. It is known to have potent bioactive properties and is used as a key intermediate in the production of several drugs and research chemicals. 5-Methoxy-2-trifluoromethylindole has also been studied for its potential applications in medicinal chemistry, particularly in the development of new drug candidates. Its unique chemical structure and reactivity make it a valuable tool in organic synthesis and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 174734-34-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,7,3 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 174734-34:
(8*1)+(7*7)+(6*4)+(5*7)+(4*3)+(3*4)+(2*3)+(1*4)=150
150 % 10 = 0
So 174734-34-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H8F3NO/c1-15-7-2-3-8-6(4-7)5-9(14-8)10(11,12)13/h2-5,14H,1H3

174734-34-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methoxy-2-(trifluoromethyl)-1H-indole

1.2 Other means of identification

Product number -
Other names 5-METHOXY-2-TRIFLUOROMETHYLINDOLE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174734-34-0 SDS

174734-34-0Downstream Products

174734-34-0Relevant articles and documents

2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp3)-H Functionalization of Trifluoroacetimidoyl Chlorides

Pedroni, Julia,Cramer, Nicolai

, p. 1932 - 1935 (2016)

Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp3)-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from

Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

Xie, Jiao-Jiao,Wang, Zhi-Qing,Jiang, Guo-Fang

, p. 35098 - 35101 (2019)

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.

An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes

Abaev, Vladimir T.,Muzalevskiy, Vasiliy M.,Nenajdenko, Valentine G.,Sizova, Zoia A.

, (2021/12/17)

The catalytic olefination reaction of 2-nitrobenzaldehydes with CF3 CCl3 afforded stereose-lectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF3-β-(2-nitroaryl) enamines. Subsequent one pot reduction of nitro-group by Fe-AcOH-H2 O system initiated intramolecular cyclization to afford 2-CF3-indoles. Target products can be prepared in up to 85% yields. Broad synthetic scope of the reaction was shown as well as some followed up transformations of 2-CF3-indole.

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