175131-61-0Relevant articles and documents
Preparation method of milnacipra hydrochloride intermediate
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Paragraph 0024-0025, (2021/10/13)
The invention provides a preparation method of an intermediate hydrochloride intermediate. Belong to chemical medicine preparation technical field. To the preparation method, the compound having the structure of the formula (II) is added into the methanol
Preparation method of 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide and salt thereof
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Paragraph 0048-0050; 0051-0074, (2020/07/15)
The invention provides a novel method for preparing 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (milnacipran) and a salt thereof. The method comprises the following steps: reducing a compound with a structure represented by a formula (I) by using a reducing agent to obtain milnacipran with a structure represented by a formula (II), and salifying milnacipran to obtain milnacipran hydrochloride. The method provided by the invention effectively controls the generation of impurities, greatly improves the yield and the purity of the product, has the characteristics of environmentalprotection, safety and economy, is suitable for industrial production, and has a wide market application prospect.
Preparation method of levomilnacipran hydrochloride
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Paragraph 0069-0070, (2018/09/28)
The invention relates to the field of chemical medicines and organic synthesis and in particular relates to a preparation method of levomilnacipran hydrochloride. Aiming at solving the problems of anexisting method for preparing the levomilnacipran hydrochloride that the cost is relatively high or a generation process is relatively dangerous so that large-scale industrial production is limited, the preparation method is characterized by comprising the following steps: [1] enabling phenylacetonitrile and (R)-2-chloromethyl ethylene oxide to react under the action of sodium amide to obtain a compound 1; then carrying out hydrolysis cyclization on the compound 1 to obtain a compound 2; [2] enabling the compound 2 and thionyl chloride to react in alcohol, so as to obtain a compound 3; [3] enabling the compound 3 to be subjected to exchange reaction through introducing nitryl and amino, so as to obtain a compound 6; [4] reducing nitryl in the compound 6 and forming salt in situ to obtain the levomilnacipran hydrochloride. The preparation method provided by the invention is applicable to industrial production of the levomilnacipran hydrochloride.