175131-61-0

Usage

Uses

Used in Pharmaceutical Industry:
(1R-cis)-Milnacipran Hydrochloride is used as a therapeutic agent for the treatment of fibromyalgia. It works by inhibiting the reuptake of norepinephrine and serotonin, which helps to alleviate the symptoms of this chronic pain disorder.
Additionally, as a selective norepinephrine and serotonin reuptake inhibitor, (1R-cis)-Milnacipran Hydrochloride may also have potential applications in the treatment of other conditions related to neurotransmitter imbalances, such as depression and anxiety. However, further research and clinical trials would be necessary to establish its efficacy and safety in these areas.

Upstream product

• 1374648-84-6 (1R,2S)-cis-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (L)-(+)-mandelate 
• 1237261-65-2 (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide-cyclopropanecarboxamide 
• 74-89-5 methylamine 
• 1374648-80-2 (1S,2R)-cis-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (D)-(-)-mandelate 
• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 96847-54-0 (1R,2S)-milnacipran 
• 105310-75-6 (1SR,2RS)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 

Relevant academic research and scientific papers

Preparation method of milnacipra hydrochloride intermediate

The invention provides a preparation method of an intermediate hydrochloride intermediate. Belong to chemical medicine preparation technical field. To the preparation method, the compound having the structure of the formula (II) is added into the methanol

Drug intermediate as well as preparation and application thereof

The invention designs a drug intermediate III, and the structural formula of the drug intermediate III is shown in the specification.

Preparation method of 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide and salt thereof

The invention provides a novel method for preparing 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (milnacipran) and a salt thereof. The method comprises the following steps: reducing a compound with a structure represented by a formula (I) by using a reducing agent to obtain milnacipran with a structure represented by a formula (II), and salifying milnacipran to obtain milnacipran hydrochloride. The method provided by the invention effectively controls the generation of impurities, greatly improves the yield and the purity of the product, has the characteristics of environmentalprotection, safety and economy, is suitable for industrial production, and has a wide market application prospect.

Preparation of leveminacipran hydrochloride

The invention discloses a novel preparation method for synthesizing leveminacipran hydrochloride, and relates to a compound represented by a formula A. According to the invention, each step of reaction is simple in operation and mild in condition, use of

Preparation method of levomilnacipran hydrochloride

The invention relates to the field of chemical medicines and organic synthesis and in particular relates to a preparation method of levomilnacipran hydrochloride. Aiming at solving the problems of anexisting method for preparing the levomilnacipran hydrochloride that the cost is relatively high or a generation process is relatively dangerous so that large-scale industrial production is limited, the preparation method is characterized by comprising the following steps: [1] enabling phenylacetonitrile and (R)-2-chloromethyl ethylene oxide to react under the action of sodium amide to obtain a compound 1; then carrying out hydrolysis cyclization on the compound 1 to obtain a compound 2; [2] enabling the compound 2 and thionyl chloride to react in alcohol, so as to obtain a compound 3; [3] enabling the compound 3 to be subjected to exchange reaction through introducing nitryl and amino, so as to obtain a compound 6; [4] reducing nitryl in the compound 6 and forming salt in situ to obtain the levomilnacipran hydrochloride. The preparation method provided by the invention is applicable to industrial production of the levomilnacipran hydrochloride.

Preparation method of levomilnacipran hydrochloride

The invention provides a preparation method of levomilnacipran hydrochloride. According to the preparation method, a mixed liquid is obtained through a mixed reaction of a compound adopting the structure shown in the formula (II) and alkali; then acid is

PROCESS FOR THE PREPARATION OF (1S,2R)-MILNACIPRAN

The invention relates to a process for the preparation of Levomilnacipran, a compound useful in the treatment of depression, comprising the following steps: a) directly converting the enantiomerically enriched form of alcohol (D) into the enantiomerically enriched form of the phthalimido derivative (C) by treatment with phthalimide in the presence of a trialkyl or triarylphosphine and of a dialkyl azodicarboxylate, formula (I) wherein the amount of phthalimide is comprised between 1 and 1.3 equivalents with respect to the molar amount of alcohol (D) used, and the amounts of both the phosphine and the azodicarboxylate are comprised, independently from each other, between 1 and 1.5 equivalents with respect to the molar amount of alcohol (D) used; b) deblocking the enantiomerically enriched form of the phthalimido derivative (C) to obtain Levomilnacipran, formula (II).

Intermediate milnacipran hydrochloride and its preparation method and application

The invention relates to the technical field of synthetic methods of milnacipran hydrochloride. The preparation method provided by the invention comprises the following steps: carrying out reactions in five steps on an existing compound to generate a nove

PROCESS FOR PREPARING LEVOMILNACIPRAN

The present invention refers to a new process for preparing levomilnacipran, in particular to a process for the resolution of racemic tw-milnacipran with a derivative of optically active phenylglycine.

AN IMPROVED PROCESS FOR THE PREPARATION OF 1-ARYL 2-AMINOMETHYL CYCLOPROPANE CARBOXYAMIDE (Z) DERIVATIVES, THEIR ISOMERS AND SALTS

The present invention relates to an improved and one-pot process for the preparation of 1-Aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers of formula (I) or its pharmaceutically acceptable salt thereof wherein R1 and R2 are represents independently selected from the group consisting of hydrogen, lower alkyl, lower aryl, and lower-alkylaryl, which aryl or alkylaryl group is optionally substituted by a halogen atom.