175278-34-9

Basic information

• Product Name: N,N'-DI(2-BROMOPHENYL)UREA
• Synonyms: N,N'-DI(2-BROMOPHENYL)UREA;N,N'-BIS-(2-BROMOPHENYL)UREA
• CAS NO: 175278-34-9
• Molecular Formula: C13H10Br2N2O
• Molecular Weight: 370.04
• Mol File: 175278-34-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 235 °C
• Boiling Point: 344.4 °C at 760 mmHg
• Flash Point: 162.1 °C
• Appearance: /
• Density: 1.829 g/cm³
• CAS DataBase Reference: N,N'-DI(2-BROMOPHENYL)UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DI(2-BROMOPHENYL)UREA(175278-34-9)
• EPA Substance Registry System: N,N'-DI(2-BROMOPHENYL)UREA(175278-34-9)

Safety Data

• Hazardous Substances Data: 175278-34-9(Hazardous Substances Data)

Usage

General Description

N,N'-di(2-bromophenyl)urea is a chemical compound that consists of two bromophenyl groups attached to a urea molecule. It is commonly used as a building block in organic synthesis and as a reagent in chemical reactions. N,N'-DI(2-BROMOPHENYL)UREA is known for its ability to form hydrogen bonds, making it a valuable tool in the creation of complex organic molecules. N,N'-di(2-bromophenyl)urea has also been studied for its potential biological and pharmaceutical applications, particularly in the field of medicinal chemistry. Overall, this chemical compound has a wide range of uses and potential in various fields of science and technology.

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Relevant articles and documents

Zinc Powder Catalysed Formylation and Urealation of Amines Using CO2 as a C1 Building Block?

Transformation of CO2 into valuable organic compounds catalysed by cheap and biocompatible metal catalysts is one of important topics of current organic synthesis and catalysis. Herein, we report the zinc powder catalysed formylation and urealation of amines with CO2 and (EtO)3SiH under solvent free condition. Using 2 molpercent zinc powder as the catalyst, a series of secondary amines, both the aromatic ones and the aliphatic ones, can be formylated into formamides. When primary aromatic amines were used as the substrates, the reactions produce urea derivatives. The electronic and steric effects from the substrates on the formylation and urealation reactions were observed and discussed. The recovery and reusability of zinc powder were investigated, showing the zinc powder can be reused in the formylation reaction without loss of catalytic activity. The analysis on the reactants/products mixture after filtering out the zinc powder showed the zinc concentration in the mixture is low to 1 ppm. The pathways for the formylation and urealation of amines with this catalytic system were also investigated, and related to the different substrates.

Synthesis of Urea Derivatives from CO2 and Silylamines

A series of thirty-three N,N′-diaryl, dialkyl, and alkyl-aryl ureas have been prepared in pyridine or toluene by reaction of silylamines with CO2. This protocol is shown to provide facile access to 13C-labeled ureas, as well as chiral and macrocyclic ureas. These reactions proceed through initial generation of the corresponding silylcarbamates, which subsequently react with silylamine under thermal conditions to afford the thermodynamically favored urea and disilyl ether.

Conformation and stereodynamics of 2,2′-disubstituted N,N′-diaryl ureas

Except in the most hindered of cases, N,N′-diaryl N,N′-dimethyl ureas adopt a conformation with the two aryl rings disposed cis to one another. Variable temperature NMR studies reveal the rate at which the Ar-N bonds rotate as well as the conformational preference of ortho disubstituted ureas in which more than one cis orientation is possible. In general, a conformation in which the aryl rings lie close in space but with their most bulky 2-substituents aligned anti is preferred, but with particularly bulky 2-substituents, conformations in which one of the aryl rings points away from the other may also be populated. The Royal Society of Chemistry.