175543-23-4

Basic information

• Product Name: Ethyl 2,2-Difluoro-2-(4-fluorophenyl)acetate
• Synonyms: Ethyl 2,2-Difluoro-2-(4-fluorophenyl)acetate
• CAS NO: 175543-23-4
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.1724696
• Mol File: 175543-23-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 232.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethyl 2,2-Difluoro-2-(4-fluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,2-Difluoro-2-(4-fluorophenyl)acetate(175543-23-4)
• EPA Substance Registry System: Ethyl 2,2-Difluoro-2-(4-fluorophenyl)acetate(175543-23-4)

Safety Data

• Hazardous Substances Data: 175543-23-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2,2-difluoro-2-(4-fluorophenyl)acetate is a chemical compound with the molecular formula C10H9F3O2. It is a colorless liquid with a fruity odor and is commonly used in the production of pharmaceuticals and agrochemicals. Ethyl 2,2-Difluoro-2-(4-fluorophenyl)acetate is a fluorinated ester, which makes it useful in the preparation of fluorinated building blocks for organic synthesis. Its primary applications include use as an intermediate in the synthesis of various pharmaceutical and agrochemical products. Ethyl 2,2-difluoro-2-(4-fluorophenyl)acetate is also known for its potential as a building block in the development of new drug molecules and other bioactive compounds.

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 667-27-6 Ethyl bromodifluoroacetate 
• 371-40-4 4-fluoroaniline 
• 1765-93-1 4-fluoroboronic acid 
• 352-13-6 4-flourophenylmagnesium bromide 
• 462-06-6 fluorobenzene 
• 698378-63-1 ethyl α,α-difluoro-α-(phenylseleno)acetate 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 1813-94-1 ethyl 4-fluorobenzoylformate 

Downstream Products

• 454483-93-3 2,2-difluoro-2-(4-fluoro-phenyl)-ethylamine 
• 94010-79-4 2,2-difluoro-2-(4-fluorophenyl)-N-methoxy-N-methylacetamide 
• 762292-74-0 2,2-difluoro-2-(4-fluorophenyl)ethanol 
• 94010-78-3 2,2-difluoro-2-(4-fluorophenyl)acetic acid 

Relevant articles and documents

A convenient synthetic approach to a novel class of aryldifluoromethyl pyrimidine derivatives containing strobilurin motif as insecticidal agents

A series of aryldifluoromethyl pyrimidine compounds containing strobilurin were synthesized through bioelectronic isometric design with azoxystrobin as the lead compound and a convenient approach to aryldifluoromethylpyrimidine intermediates was developed, which features mild reaction conditions and simple operation. The title compounds and aryldifluoromethylpyrimidine intermediates were characterized by NMR and HRMS. Both 7c and 7l of the preliminary screening tests showed 100% inhibition against Mythimna separata at 100 mg/L. At 20 mg/L, the lethal rate of 7l against Mythimna separata can be up to 80%.

Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenyl ethan-1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.

Easy Access to Difluoromethylene-Containing Arene Analogues through Palladium-Catalysed C–H Olefination

An efficient palladium-catalysed ortho-C–H olefination of α,α-difluorophenylacetic acid derivatives using 8-aminoquinoline as a bidentate directing group has been developed. A range of olefinated arenes can thus be synthesized in a concise way. This reaction provides an easy and straightforward route to a panel of difluoromethylated arene analogues in moderate to good yields, with a satisfactory tolerance of common functional groups. Transformation of the products into a variety of other difluoromethylene-containing compounds demonstrates the utility of this method.