17556-48-8Relevant articles and documents
The influence of fluorine on the asymmetric reduction of fluoromethyl ketones
Ramachandran, P. Veeraraghavan,Gong, Baoqing,Teodorovi?, Aleksandar V.
, p. 844 - 850 (2007)
A comparative study of the asymmetric reduction of representative aryl and alkyl α-fluoro- and α-chloromethyl ketones using (-)-diisopinocampheylchloroborane [(-)-DIP-Chloride] and (-)-B-isopinocampheyl-9-borabicyclo[3.3.1]nonane [R-Alpine-Borane] has been made. It was observed that DIP-Chloride is superior in terms of the rate and enantioselectivity for both classes of halo-ketones. While the reduction of monofluoroacetone and trifluoroacetone with DIP-Chloride provided the product alcohols in 61% ee and 96% ee, respectively, the reduction of difluoroacetone yielded only 5% ee. The influence of a lone halogen atom was not observed for monochloroacetone, all of which point towards a chelating effect of monofluoroacetone on the Lewis acidic chloroborane.
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Crawford,J.W.C.
, p. 2332 - 2333 (1967)
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ION CHANNEL MODULATORS
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Page/Page column 38, (2021/06/04)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.
COMPOUNDS AND THEIR METHODS OF USE
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Paragraph 0243; 0245, (2020/12/13)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.
ION CHANNEL MODULATORS
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Paragraph 00424, (2019/12/25)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.