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17556-48-8

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17556-48-8 Usage

Uses

(S)-1,1,1-Trifluoro-2-propanol can be used as ion channel modulators to treat neurological disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 17556-48-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,5,5 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17556-48:
(7*1)+(6*7)+(5*5)+(4*5)+(3*6)+(2*4)+(1*8)=128
128 % 10 = 8
So 17556-48-8 is a valid CAS Registry Number.

17556-48-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-1,1,1-TRIFLUORO-2-PROPANOL

1.2 Other means of identification

Product number -
Other names 2-Propanol, 1,1,1-trifluoro-, (±)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17556-48-8 SDS

17556-48-8Relevant articles and documents

The influence of fluorine on the asymmetric reduction of fluoromethyl ketones

Ramachandran, P. Veeraraghavan,Gong, Baoqing,Teodorovi?, Aleksandar V.

, p. 844 - 850 (2007)

A comparative study of the asymmetric reduction of representative aryl and alkyl α-fluoro- and α-chloromethyl ketones using (-)-diisopinocampheylchloroborane [(-)-DIP-Chloride] and (-)-B-isopinocampheyl-9-borabicyclo[3.3.1]nonane [R-Alpine-Borane] has been made. It was observed that DIP-Chloride is superior in terms of the rate and enantioselectivity for both classes of halo-ketones. While the reduction of monofluoroacetone and trifluoroacetone with DIP-Chloride provided the product alcohols in 61% ee and 96% ee, respectively, the reduction of difluoroacetone yielded only 5% ee. The influence of a lone halogen atom was not observed for monochloroacetone, all of which point towards a chelating effect of monofluoroacetone on the Lewis acidic chloroborane.

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Crawford,J.W.C.

, p. 2332 - 2333 (1967)

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ION CHANNEL MODULATORS

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Page/Page column 38, (2021/06/04)

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

COMPOUNDS AND THEIR METHODS OF USE

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Paragraph 0243; 0245, (2020/12/13)

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

ION CHANNEL MODULATORS

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Paragraph 00424, (2019/12/25)

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

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