17722-14-4

Usage

Uses

Used in Organic Synthesis:
N,N''-BIS-(3-CHLORO-PHENYL)-MALONAMIDE is used as a reagent in organic synthesis for its ability to participate in a wide range of chemical reactions, facilitating the production of pharmaceuticals and agrochemicals. Its unique structural features contribute to its effectiveness in these applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N''-BIS-(3-CHLORO-PHENYL)-MALONAMIDE is used as a key intermediate in the synthesis of various drug molecules. Its role in organic synthesis makes it instrumental in creating complex pharmaceutical compounds.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, N,N''-BIS-(3-CHLORO-PHENYL)-MALONAMIDE is utilized as a reagent for the synthesis of agrochemicals, such as pesticides and herbicides, due to its ability to enhance the properties of these compounds.
Used as a Chelating Agent:
N,N''-BIS-(3-CHLORO-PHENYL)-MALONAMIDE is used as a chelating agent for metal ions, which is important in various chemical processes where metal ion sequestration is necessary to prevent unwanted side reactions or to improve the efficiency of certain reactions.
Used as a Catalyst:
Furthermore, it serves as a catalyst in a variety of chemical transformations, accelerating the rate of reactions without being consumed in the process, which is vital for improving the efficiency of chemical processes in both research and industrial settings.
Safety Considerations:
Due to the potential hazards associated with N,N''-BIS-(3-CHLORO-PHENYL)-MALONAMIDE, it is essential to handle N,N''-BIS-(3-CHLORO-PHENYL)-MALONAMIDE with care, following proper safety protocols to minimize risks to both individuals and the environment.

Upstream product

• 504-64-3 carbon suboxide 
• 108-42-9 3-chloro-aniline 
• 105-53-3 diethyl malonate 
• 108-59-8 malonic acid dimethyl ester 
• 60-29-7 diethyl ether 
• 621-10-3 N,N'-diphenylmalonamide 
• 67-66-3 chloroform 
• 7790-99-0 Iodine monochloride 

Downstream Products

• 138574-51-3 2,2-Diamino-N,N'-bis-(3-chloro-phenyl)-malonamide 

Relevant academic research and scientific papers

HCV NS3 protease inhibitors

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

HCV NS3 PROTEASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors

HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site.

SUBSTITUTED 2-ARYLMETHYLENE-N-ARYL-N'-ARYL-MALONAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS

The present invention is directed to substituted 2-arylmethylene-N-aryl-N'-aryl-malonamides and analogs thereof. The present invention also relates to the discovery that the compounds are activators of caspases and inducers of apoptosis. Therefore, the activators os caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of anormal cells occurs.

Synthesis of Benzo-halogenated 4-Hydroxy-2(1H)-quinolones

Malondianilides 3 derived from dichloro substituted anilines 2 undergo cyclization to afford 4-hydroxy-2(1H)-quinolones 4 in very good yields using methane sulfonic acid-phosphorus pentoxide as catalyst. 3,4-Dichloro anilines 5 can be shown to yield two i