17734-21-3

Usage

Uses

Used in Organic Synthesis:
Benzenepentanamine is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of a wide range of organic compounds.
Used in Pharmaceutical Production:
Benzenepentanamine is used as a precursor in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds due to its unique chemical structure.
Used in Agrochemical Production:
In the agrochemical industry, Benzenepentanamine is utilized as a starting material for the synthesis of various agrochemicals, helping to create products that contribute to crop protection and enhancement of agricultural yields.
Used in Other Organic Compounds Production:
Beyond its applications in pharmaceuticals and agrochemicals, Benzenepentanamine is also employed in the synthesis of other organic compounds, highlighting its versatility in the realm of chemical manufacturing.

InChI:InChI=1/C11H17N/c12-10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10,12H2

Upstream product

• 14469-83-1 (5-bromopentyl)benzene 
• 127611-46-5 ((Z)-5-Azido-pent-1-enyl)-benzene 
• 10521-91-2 5-phenylpentan-1-ol 
• 118647-85-1 1-(5-azidopentyl)benzene 
• 75803-20-2 methansulfonic acid 5-phenyl-pentyl ester 
• 1823-14-9 5-phenyl-1-pentyne 
• 7726-45-6 5-phenylvaleronitrile 
• 637-59-2 1-Bromo-3-phenylpropane 
• 856348-73-7 6-(4-amino-phenyl)-hexanoic acid 
• 15733-63-8 5-chloropentylbenzene 
• 53429-14-4 2-(5-phenylpentyl)isoindoline-1,3-dione 
• 95109-78-7 4-(5-amino-pentyl)-aniline 
• 36603-28-8 5-phenylpentanitrile 

Downstream Products

• 100794-46-5 3-chloro-propionic acid-(5-phenyl-pentylamide) 
• 143769-68-0 2-Phenyl-ethanesulfonic acid (5-phenyl-pentyl)-amide 
• 98510-42-0 2-Amino-5-nitroso-6-(5-phenyl-pentylamino)-3H-pyrimidin-4-one 
• 82173-88-4 C₂₂H₃₃N₃O₄S₂ 
• 143769-86-2 6-(5-Phenyl-pentyl)-5,6,8,9-tetrahydro-7-thia-6-aza-benzocycloheptene 7,7-dioxide 
• 144290-37-9 N-Benzoyl-N'-[3-(1H-imidazol-4-yl)-propyl]-N''-(5-phenyl-pentyl)-guanidine 
• 144477-84-9 N-[3-(1H-Imidazol-4-yl)-propyl]-N'-(5-phenyl-pentyl)-guanidine; hydrochloride 
• 98455-88-0 2-[N-(5-Phenylpentylamino)]-5-hydroxy-4-methylpyrimidine 
• 1147130-30-0 N-(5-phenylpentyl)-quinoline-6-carboxamide 
• 1147130-43-5 N-(5-phenylpentyl)-[1,5]naphthyridine-2-carboxamide 

Relevant academic research and scientific papers

Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis

A general and efficient method for heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis to access a wide range of structurally diverse oxygen as well as nitrogen heterocycles up to a gram scale is reported. The potential application of this new methodology is demonstrated by the total synthesis of (-)-codonopsinine and (+)-centrolobine. Herein it is proposed that selectfluor, unlike a fluorinating reagent, acts as an oxidative quencher and a hydrogen radical acceptor.

A Practical Electrophilic Nitrogen Source for the Synthesis of Chiral Primary Amines by Copper-Catalyzed Hydroamination

A mild and practical method for the catalytic installation of the amino group across alkenes and alkynes has long been recognized as a significant challenge in synthetic chemistry. As the direct hydroamination of olefins using ammonia requires harsh conditions, the development of suitable electrophilic aminating reagents for formal hydroamination methods is of importance. Herein, we describe the use of 1,2-benzisoxazole as a practical electrophilic primary amine source. Using this heterocycle as a new amino group delivery agent, a mild and general protocol for the copper-hydride-catalyzed hydroamination of alkenes and alkynes to form primary amines was developed. This method provides access to a broad range of chiral α-branched primary amines and linear primary amines, as demonstrated by the efficient synthesis of the antiretroviral drug maraviroc and the formal synthesis of several other pharmaceutical agents.

meta-Selective C?H Borylation of Benzylamine-, Phenethylamine-, and Phenylpropylamine-Derived Amides Enabled by a Single Anionic Ligand

Selective functionalization at the meta position of arenes remains a significant challenge. In this work, we demonstrate that a single anionic bipyridine ligand bearing a remote sulfonate group enables selective iridium-catalyzed borylation of a range of common amine-containing aromatic molecules at the arene meta position. We propose that this selectivity is the result of a key hydrogen bonding interaction between the substrate and catalyst. The scope of this meta-selective borylation is demonstrated on amides derived from benzylamines, phenethylamines and phenylpropylamines; amine-containing building blocks of great utility in many applications.

ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS

The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I

ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS

The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases

Fatty acid amide hydrolase (FAAH, EC 3.5.1.99) is the main enzyme catabolizing endocannabinoid fatty acid amides. FAAH inactivation promotes beneficial effects upon pain and anxiety without the side effects accompanying agonists of type-1 cannabinoid receptors. Aiming at discovering new selective FAAH inhibitors, we developed a series of compounds (5a-u) characterized by a functionalized heteroaromatic scaffold. Particularly, 5c and 5d were identified as extremely potent, noncompetitive, and reversible FAAH inhibitors endowed with a remarkable selectivity profile and lacking interaction with the hERG channels. In vivo antinociceptive activity was demonstrated for 5c, 5d, and 5n at a dose much lower than that able to induce either striatal and limbic stereotypies or anxiolytic activity, thus outlining their potential to turn into optimum preclinical candidates. Aiming at improving pharmacokinetic properties and metabolic stability of 5d, we developed a subset of nanomolar dialyzable FAAH inhibitors (5v-z), functionalized by specific polyethereal lateral chains and fluorinated aromatic rings.

Efficient conversion of primary and secondary alcohols to primary amines

A convenient single-vessel conversion of primary and secondary alcohols to primary amines is reported. Use of this method results in substantially cleaner crude products than similar procedures reported in the literature. A simple work-up also makes this procedure ideal for parallel synthesis.

SbCl5-wet acetonitrile: A new system for chemoselective O-desilylation

A new efficient method for deprotection of TBDMS derivatives of phenols, primary alcohols, carboxylic acids and secondary amines, consisting of SbCl 5 and MeCN with 0.1% water (w/v), is reported. It effects inter alia desilylation of a CH2OTBDMS group in the presence of a ketal function.

Imidazole compounds

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Piperidine-containing histamine H3-receptor antagonists of the carbamate series: Variation of the spacer length

Ten carbamate derivatives have been prepared from appropriate isocyanates and ω-piperidino-1-alkanols. All compounds belong to the new generation of non-imidazole histamine H3-receptor ligands which may have beneficial pharmacokinetic properties compared with the classical imidazole-containing H3-receptor antagonists. The carbamates were evaluated in vitro for antagonist activity at guinea-pig (gp) H3, H2, H1, and M3 receptors, respectively. They displayed moderate affinity for H3 receptors (pA2 5.8-7.0 in the gp ileum assay) as well as low to moderate selectivities vis-a-vis H2 (gp atrium), H1 (gp ileum), and M3 (gp ileum) receptors. A typical member of this series is 7-piperidino-1-heptyl N-(4-phenyl-1-butyl)carbamate (17) with pA2 values of 7.02 (H3), 5.92 (H1), and 6.38 (M3), respectively, and a pD'2 value of 5.46 (H2).