3049-24-9Relevant articles and documents
Direct18F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F-on Phosphonate Prostheses
Wang, Chao,Zhang, Lei,Mou, Zhaobiao,Feng, Wanru,Li, Zhongjing,Yang, Hongzhang,Chen, Xueyuan,Lv, Shengji,Li, Zijing
supporting information, p. 4261 - 4266 (2021/05/26)
We describe a high radiochemical yield late-stage direct 18F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other electrophiles by F- at various hydrogen bond forms. Rapid access to many medicinally significant 18F-labeled biomolecules is achieved at 21-68% radiochemical yields and 35.9-55.1 GBq μmol-1 molar activities both manually or automatically.
Preparation method of phenyl phosphonate diphenyl ester (by machine translation)
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Paragraph 0045-0052; 0057-0085; 0093-0096, (2020/09/16)
The invention belongs to the technical field of organic synthesis, and provides a preparation method of diphenyl phosphonate, wherein triphenyl phosphite is used as an initiator, and the molar ratio ?timetime? and isomerization reaction is controlled to obtain phenyl phosphonate diphenyl ester; the isomerization reaction temperature is 220 - 260 °C. the isomerization reaction temperature is controlled; 1st. In addition, both the brominated benzene and Raney nickel in the method can be recycled, the reaction cost is low, and the environmental pollution is small. (by machine translation)
Cobalt catalyzed C-P bond formation by cross-coupling of boronic acids with P(O)H compounds in presence of zinc
Hicks, Ian,McTague, Jonathan,Hapatsha, Tatiana,Teriak, Rania,Kaur, Parminder
, (2020/01/31)
In our current work, we have reported the first cobalt-catalyzed cross-coupling of arylboronic acid with alkyl/aryl phosphites under mild conditions. The reaction was carried out in the presence of zinc powder as an additive and ter-pyridine as a ligand. The use of non-precious cobalt salt makes the protocol advantageous, as it is inexpensive and more abundant than the previously used methods where precious metal salts (Pd and Pt) were used. The reaction has a wide substrate scope and the products were obtained in good yields.
