17799-96-1Relevant academic research and scientific papers
A convenient synthesis of 1H-2,3-benzoxazines by an acid-catalyzed intramolecular Mitsunobu reaction
Kai, Hiroyuki,Nakai, Toru
, p. 6895 - 6897 (2001)
A convenient, efficient method for the preparation of benzoxazines is described. 2-(Hydroxyiminomethyl)benzyl alcohols were cyclodehydrated to construct 1H-2,3-benzoxazines by acid-catalyzed intramolecular Mitsunobu reaction. This reaction depended on the
Palladium-catalyzed direct mono -aroylation of O -arylmethyl and aryl-substituted acetoxime ethers
Shao, Ling-Yan,Xu, Zhi,Wang, Cun-Ying,Fu, Xiao-Pan,Chen, Miao-Miao,Liu, Hong-Wei,Ji, Ya-Fei
, p. 6284 - 6294 (2018)
An efficient palladium-catalyzed ortho-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers has been developed; this method has high mono-site selectivity and does not require exogenous ligands. Under the direction of a simple exo-acetoxime auxiliary, a broad scope of masked arylmethyl alcohols and phenols as well as various aromatic aldehydes are compatible with this transformation, which probably follows a mechanistic pathway involving a six- or five-membered exo-cyclopalladated intermediate. The strategy can be expediently adopted to prepare synthetically valuable 1H-benzo[d][1,2]oxazines and benzo[d]isoxazoles. The directing group can be easily removed from the products to afford the functionalized diaryl ketones.
Iridium-Catalyzed Acid-Assisted Hydrogenation of Oximes to Hydroxylamines
Cope, Christopher J.,Cramer, Nicolai,Mas-Roselló, Josep,Pinson, Benjamin,Robinson, Alan,Smejkal, Tomas,Tan, Eric
supporting information, p. 15524 - 15532 (2021/06/11)
We found that cyclometalated cyclopentadienyl iridium(III) complexes are uniquely efficient catalysts in homogeneous hydrogenation of oximes to hydroxylamine products. A stable iridium C,N-chelation is crucial, with alkoxy-substituted aryl ketimine ligand
