21653-11-2Relevant academic research and scientific papers
N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase
Nencetti, Susanna,La Motta, Concettina,Rossello, Armando,Sartini, Stefania,Nuti, Elisa,Ciccone, Lidia,Orlandini, Elisabetta
, p. 3068 - 3076 (2017/05/25)
Aldose reductase (ALR2), a NADPH-dependent reductase, is the first and rate-limiting enzyme of the polyol pathway of glucose metabolism and is implicated in the pathogenesis of secondary diabetic complications. In the last decades, this enzyme has been ta
Synthesis and antimicrobial properties of cephalosporin derivatives substituted on the C(7) nitrogen with arylmethyloxyimino or arylmethyloxyamino alkanoyl groups
Gentili, Daniela,Macchia, Marco,Menchini, Elisabetta,Nencetti, Susanna,Orlandini, Elisabetta,Rossello, Armando,Broccali, Giampietro,Limonta, Donatella
, p. 224 - 231 (2007/10/03)
Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the ap
α-Functionalized Amino Acid Derivatives. A Synthetic Approach of Possible Biogenetic Importance
Herscheid, Jacobus D. M.,Nivard, Rutger J. F.,Tijhuis, Marian W.,Scholten, Henk P. H.,Ottenheijm, Harry C. J.
, p. 1880 - 1885 (2007/10/02)
A new and efficient approach of general applicability to the synthesis of α-functionalized α-amino acid derivatives 3 is described.It is based upon the proposal that the biosynthesis of such compounds might occur via oxidation of an N-acylated amino acid
